结合磁共振成像和脑机接口的新型在体生物电子鼻的研究

doi:10.3969/j.issn.0258-8021. 2018. 01.008

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Abstract By using mammal′s own olfactory system, sensitivity and specificity of the in vivo bioelectronic nose is substantially enhanced. However, the specific region in the olfactory bulb where to implant the electrode has been based on the researcher′s experiences, which often results in unsatisfied success rate. This study takes advantage of the paramagnetism and calcium ion similarity of the manganese ion. A small dose of manganese ion was delivered into the right naris of 10 rats, an odor was delivered to the nose of the rat, and a series of magnetic resonance images (MRI) were taken. With the MRI data, a region in the olfactory bulb activated by the specific odor was identified. Micro-wire electrode was implanted into the region and olfactory signals were recorded. When the rat was stimulated by the specific odor, the β wave of the LFP was found to increase and the spike signals also had responses. Linearity was observed between the difference of the spike-firing rate caused by the odor stimulation and the concentration of the odor. The limits of detection to isoamyl acetate and n-butyric acid were determined to be 0.033μM and 0.0072μM, respectively. As the first bioelectronic nose assisted by manganese-enhanced MRI, it has a promising future in explosives searching or food safety.

Key words： in vivo bioelectronic nose odor detection MEMRI brain-computer interface electrophysiology

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R318

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	Articles by authors
	Zhang Bin
	Wu Zhe
	He Hongjian
	Ding Qiuping
	Qin Zhen
	Gao Keqiang
	Zhong Jianhui
	Wang Ping

Cite this article:

Zhang Bin,Wu Zhe,He Hongjian, et al. Characterization of in vivo Bioelectronic Nose with Combined #br# Manganese-Enhanced MRI and Brain-Computer Interface[J]. Chinese Journal of Biomedical Engineering, 2018, 37(1): 57-63.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2018. 01.008 OR http://cjbme.csbme.org/EN/Y2018/V37/I1/57

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