基于卷积神经网络的外周血白细胞分类

doi:10.3969/j.issn.0258-8021. 2018. 01.003

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Abstract The automatic classification of white blood cell (WBC) image is essential because it helps to enhance the efficiency of clinical diagnosis and treatment. However, the classification accuracy is still need to be boost for adapting to practical applications. In this paper, we proposed an automatic classification method based on the convolution neural network (CNN). We tentatively fed our training dataset into AlexNet and LeNet using a widely used deep learning platform Caffe. Five classes of WBCs images collected by a CellaVision DM96 in peripheral blood smears were adopted as the training dataset. These manual labeled images were apportioned into three groups (training, validation and testing) randomly to construct the original dataset according to the proportion of 7：2∶1. With the augmentation methods, such as rotation and mirror, we expanded the original dataset. Stochastic gradient descent algorithm was adopted as the optimizing method for training CNNs. The experimental results demonstrated that the network structure of AlexNet was unsuitable to achieve the ideal classification accuracy which more than 95%. While the network structure of LeNet had achieved the expected target. However, the more massive and more time consuming of LeNet suggested us to further optimize the connection of layers to derive a new network with lightweight structure, named as CCNet. The model size, time for training, and time for evaluation of CCNet were only 1/1000, 1/3, and 1/30 compared with LeNet, respectively. The best classification accuracy of CCNet and LeNet for five classification of WBCs was 99.69% and 99.18% with 979 WBC images, higher than those of the previous reports. It demonstrated that CNNs especially CCNet had clear advantages than previous works both in classification accuracy and speed.

Key words： deep learning convolution neural network leukocyte morphology classification

Received: 11 October 2016

PACS:

R318

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	Articles by authors
	Chen Chang
	Cheng Shaojie
	Li Weibin
	Chen Min

Cite this article:

Chen Chang,Cheng Shaojie,Li Weibin, et al. A Peripheral Blood WBC Classification with ConvolutionalNeural Network[J]. Chinese Journal of Biomedical Engineering, 2018, 37(1): 17-24.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2018. 01.003 OR http://cjbme.csbme.org/EN/Y2018/V37/I1/17

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