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| Effects of Fear Memory Formation on Local Field Potential in Rat Prefrontal Cortex |
| Zhang Bingshu, Sui Li*, Huang Sijia |
| (School of Medical Instrumentation and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China) |
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Abstract In this work, characteristics of local field potential before and after fear memory formation were studied to investigate the effects of fear memory formation on local field potential in rat medial prefrontal cortex. Eight healthy adult male SD rats were selected. The electrodes were implanted into the medial prefrontal cortex of the rats by stereotaxic apparatus. After one week, shuttle box test was used to induce fear memory in rats when rats were awake. The local field potential of rat medial prefrontal cortex was monitored by using Cerebus neural signals recording system, before and 6 h, 1 d, 2 d, 3 d, 4 d, 5 d, 6 d after fear memory formation. The Neuroexplorer software was introduced to analysis the local field potential. Power spectral density and power percentage of local field potentials were analyzed and compared with total power before and after the formation of fear memory and among different frequency bands (δ: 1-3 Hz, θ: 4-7 Hz, α: 8-13 Hz, β: 14-30 Hz, γ: 31-100 Hz). The results showed that the power percentage of θ and β at 6 h after fear memory formation was significantly different from that of before fear memory formation (P=0.017, P=0.017); The power percentage of θ was increased than that before fear memory formation. The power percentage of β was reduced than before fear memory formation. In addition, the power percentage of δ 1-2 days after fear memory formation was significantly different from that before fear memory formation (P=0.03, P=0.049). The power percentage of γ on 1～2 days after fear memory formation was significantly different from that before fear memory formation (P=0.013, P=0.019).These results indicated that activating mode of neural information processing in rat medial prefrontal cortex was significantly altered following fear memory formation.
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Received: 21 April 2016
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