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| Current Research on Local Field Potential Rhythms of Deep Brain Stimulation Indications |
| Chen Yue1 Qian Xing1 Hao Hongwei1# Li Luming1,2#* |
1National Engineering Laboratory for Neuromodulation, Beijing 100084, China
2Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China |
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Abstract As a technology of neuromodulation, Deep Brain Stimulation (DBS) has become an established clinical treatment for brain disorders and opened a window of brain for neuroscience researchers. In this article, current treatment status and pathology hypothesis of 4 FDA-approved brain disorders are briefly introduced, including the Parkinson disease (PD), dystonia, essential tremor and obsessive compulsive disorder (OCD). The LFP theta, alpha, beta, gamma and other high frequency rhythms of the above diseases are summarized as well. Relevance between the LFP rhythms and clinical symptoms or behaviors is analyzed. The latest implantable LFP research tool and the real-time collection results are introduced. In conclusion, the LFP rhythms of DBS targets or related areas could reflect characteristics of different brain disorders. These electrophysiological rhythms will make the foundation for the pathological study, DBS mechanism exploration and theoretical development of neuromodulation. At last, based on the limits of the current researches, this article proposes some prospect of LFP rhythm study, which would be of great significance to the field of neuromodulation.
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Received: 24 March 2015
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