酗酒者皮层脑电同步性分析

doi:10.3969/j.issn.0258-8021.2016.06.005

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Abstract Synchronization can measure the interaction between different brain regions. However, existing synchronization analyses on EEG synchronization are almost all based on the scalp EEG data. Due to the volume conductor effect, pseudo relevance between the scalp electrodes may occur, which further affects the measurement of synchronization. In this study, we selected the 61 channel EEG time series data of both the control subjects (28) and the alcoholics (28). For each trial, the subject was exposed to one of the following three different stimuli: a single stimulus (S1), two matched stimuli (S2 match), or two non-matched stimuli (S2 no match). The study used eLoreta and the self-defined 61 ROI (regions of interested) in the cerebral cortex. The synchronization between ROIs and the synchronization difference between alcoholic subjects and controls (non-alcoholics) during certain cognitive tasks were measured. Results indicated that the synchronization for the alcoholic group was lower than in the control group when performing the same cognitive task, the difference was statistically significant with α, β1 and θ band (P<0.05). The synchronization for the control group can reflect the complexity levels of the cognitive tasks (S2 match > S2 no match > S1), whereas the alcoholics only displayed erratic changes when the different cognitive tasks performed. The brain regional MSL between different subjects indicated that the alcoholic group was lower than control group when the S2 match performed,and in α band, frontal, left temporal area, central and right temporal area have significant differences (P<0.05); in β1 band, frontal showed significant differences (P<0.05); in β2 band, both frontal and left temporal area showed significant differences (P<0.05). These results indicate that in alcoholics, brain synchronization was reduced, and the connection between different brain regions was inhibited, meaning brain cognitive function is impaired. Our research provides indicated that long-term alcoholism causes functional damage to the brain from an entirely new perspective.

Key words： alcoholics cortical EEG synchronization

Received: 04 January 2016

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R318

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	Liu Guiqing Cao Rui Xiang Jie

Cite this article:

Liu Guiqing Cao Rui Xiang Jie. Synchronization in Alcoholics Using Cortical EEG[J]. Chinese Journal of Biomedical Engineering, 2016, 35(6): 671-676.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2016.06.005 OR http://cjbme.csbme.org/EN/Y2016/V35/I6/671

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