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Shearing Device for in-vitro Simulation of Mechanical Blood Damage: A Review |
Chen Xi, Yin Chengke*, Wu Peng, Xu Boling |
(School of Mechanical and Electrical Engineering, Laboratory of Artificial Organ Technology, Soochow University, Suzhou 215021, Jiangsu, China) |
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Abstract Due to the increase of dietary changes and aging population, cardiovascular disease (CVD) has surged in modern society. Mechanical circulatory support devices (MCSDs) have become a viable therapeutic solution to assist or replace the failing heart and/or lung, maintaining patients′ physiological circulation. Despite that MCSDs have been developed as bridges to save patients′ lives, blood damage due to non-physiological high shear stress in the flow field within MCSDs has been a major disadvantage. To date, the underlying mechanism has not been studied thoroughly. Therefore, various types of blood shearing devices (BSDs) have been developed. In this paper, a number of representative BSDs were reviewed, including cone-plate and annular Couette types of BSDs. The annular Couette BSDs that are being widely-used were discussed in details. Furthermore, this review discussed the influence of certain parameters and experimental setup on the results. At last, from gap precision, flow design, method of seal and support, even temperature controlling, an outlook for future BSDs was given.
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Received: 18 September 2015
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