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| Preparation and Characterization of PSF Hollow Fiber Hemodialysis Membrane |
| Pan Zhenqiang1, Ma Xiaohua1, Xu Zhenliang1*, Jiang Banghe2 |
1(State Key Laboratory of Chemical Engineering, Shanghai Key Laboratory of Multiphase Structural Materials, Membrane Science and Engineering R&D Lab, Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237, China)
2(Huachang Polymers L.L.C, Shanghai 200237, China) |
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Abstract A novel hollow fiber hemodialysis membrane was fabricated for medical applications. The polysulfone(PSF) membrane was prepared by nonsolvent-induced phase separation (NIPS) method using diethylene glycol (DEG) as the pore former, polyvinyl pyrrolidone (PVP-K30) as the modification agent and dimethylacetamide (DMAC) as a solvent. The effect of PSF content on the morphology, permeation performance,hydrophilicity and mechanical strength of the prepared PSF membranes was characterized by scanning electron microscopy (SEM), dialysis test, contact angle, porosity and tensile test, respectively. In order to test the effects of membrane dialysis properties, the dialysis tests were conducted by using the simulated solutions containing creatine, phosphate and VB12. The pore size and molecular weight cut-off(MWCO) were obtained from the rejections of the different PEG molecular weights (MW 1 000,2 000, 4 000, 6 000, 10 000, 20 000) in the ultrafiltration experiment. The experimental results showed that the optimal mass fraction of the casting solutions was following: 21% for PSF, 10% for DEG and 10%for PVP. The ultrafiltration coefficient, break strength, pore size and MWCO of the membrane reached 185.1mL/m2·h·mmHg, 5.22 MPa, 5.00nm and14 200, respectively. Besides, the membrane also had ideal clearance of solutes for creatine, phosphate and VB12. The good permeability performance and the excellent mechanical property were suitable for hemodialysis.
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Received: 24 September 2015
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