Research Progress of Chitosanbased Nanomaterials in Bone Tissue Engineering and Regenerative Medicine
1 Department of Prosthetic Dentistry, College of Medicine, Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, China
2 Department of Oral Surgery, First People’s Hospital of Hangzhou, Hangzhou 310006, China
3 ZhejiangCalifornia International Nanosystems Institute, Zhejiang University, Hangzhou 310029, China
Abstract Chitosan is the only one natural cationic polysaccharide possessing similar chemical structures to extracellular glycosaminoglycan. Chitosan has excellent biocompatibility, biodegradability as well as biological activity. In the past decade, chitosanbased nanomaterials have been widely studied in bone tissue engineering. The present paper reviews the researches and application potentials of chitosan nanocomposites, chitosan nanofibers and chitosan nanoparticles in biomedical fields. Investigation results show that chitosan nanocomposites, chitosan nanofibrous scaffolds and chitosan nanoparticles loading biological active factors and exogenous genes have wide promising potentials for bone tissue engineering and regenerative medicine.
LI Xiao Jing1 WANG Xin Mu2 DONG Yan1*GOU Zhong Ru3. Research Progress of Chitosanbased Nanomaterials in Bone Tissue Engineering and Regenerative Medicine[J]. journal1, 2013, 32(5): 620-625.
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