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| Cortical Networks of the Elderly with Mild Cognitive Impairment by Partial Directed Coherence Analysis of EEG |
1 School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China
2 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
3 Beijing Key Laboratory of Neuromodulation, Beijing 100053, China |
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Abstract The deficiency of brain connectivity has been discovered in cognitive processing of MCI in recent research. It is still unclear that how different brain regions influence each other and what causality is in the brain regions. The aim of this study was to analyze electroencephalography (EEG) directed cortical networks under cognitive task. Thirty elders, including 9 patients with MCI and 21 normal controls, participated in the experiment. We recorded their scalp EEG when they were judging whether the color of two graphics was matched or not. The first 1 seconds EEG data after the stimulus onset were extracted to calculate Partial Directed Coherence. Results showed that the deficiency information flow of right prefrontal cortex and abnormal enhance information flow of left central area were observed in MCI; The input degrees of the front hemisphere were higher than the back hemisphere in both controls and patients. The input degrees of right hemisphere were higher than left hemisphere in controls，but there were not significant differences in patients. Under specific threshold: the input degrees of left hemisphere in controls were lower than MCI under match task (threshold was 0.14, F=3.780，P=0.040); the input degrees of left hemisphere in controls were lower than MCI under no match task (threshold was 0.26, F=3.280，P=0.040); the input degrees of right hemisphere in controls were lower than MCI under no match task (threshold was 0.18, F=3.941，P=0.021). We used the input degree to prove that the MCI had the deficit in right hemisphere under color cognitive task.
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