Abstract In this work heparin–conjugating phenylalanine was linked to chloromethyl resin to prepare a new, safe, nontoxic adsorbent for endotoxin clearance. The optimal experimental conditions were determined by changing the amounts of reactants, reaction time and pH value. The performance of the heparinconjugating phenylalanine adsorbent were studied under the conditions of being in water and blood plasma, different initial concentration of endotoxin and the different lasting time. Additionally blood compatibility of the absorbent was evaluated. In dialyzing imitation experiments in water and in rabbit plasma, the endotoxin concentration was reduced to a low level after 2 hours of absorbent exposure. The maximum clearance rate was up to 79% and 72% in water and in the plasma respectively. The influence of the absorbent upon the concentrations of other substances in the blood was below 10%, showing excellent blood compatibility
JIN Xin Xin1 WANG Xiang1* MAO Jin Chun1 TANG Fu Zhou1 XIONG Yan Lian1. Research of HeparinConjugating Phenylalanine Blood Purification Material to Remove Endotoxin[J]. journal1, 2013, 32(3): 348-355.
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XU Chuang Ye1,2LIU Xiu Jian1,2WU Guang Hui1,2HOU Xiao Tong1 LI Hai Yang1YANG Peng3 LIN Chang Yan1,2#*Preclinical Study of Anticoagulation Regimens in Animals after Implantation of CHVAD[J]. journal1, 2014, 33(5): 585-592.
