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| A Hemodynamic Model for Simulation of Cerebral Blood Flow and Ventricular Power Changes in Stroke |
| Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China |
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Abstract The aim of this work is to analyze the effect of stroke on the ventricular work and the correlation with hypertension and to provide the hemodynamic evidences for the precaution of stroke and cardiovascular diseases. A dynamic model for heart and cerebrovascular coupling was proposed based on asymmetric Ttube model, and its arterial hemodynamic behaviors were computed and analyzed. Changes of the pressure, cerebral blood flow and ventricular power were simulated by altering the level of cerebral arterial resistance and compliance. Results showed that cerebral peripheral resistance in patients with stroke was significantly higher than that in the normal. The patients whose cerebral peripheral resistance was more than twice of normal value was 83% of the total. Blood pressure in stroke, especially the systolic pressure and the pulse pressure, was significantly higher than that of the normal. The systolic pressure was higher than 140 mmHg according to the simulated results. Compensatory flow and autoregulation existed in cerebral circulation. Ventricular power as well as the proportion of the pulsatile to total power increased with the increment higher than 10%. The cerebral pathological change in stroke was closely associated with hypertension and affected the ventricular work. Thereofore in the treatment of stroke, heart protection should also be strengthened.
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