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| Electronic Clinical Guideline Embedded Heart Failure Treatment |
1 Department of Biomedicine Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University， Hangzhou 310027, China
2 ICU Department, Zhejiang Hospital, Hangzhou 310013, China |
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Abstract In this paper, a heart failure (HF) treatment model based on electronic clinical guideline was proposed to realize personalized therapy. Integrated with clinical guideline of HF, a multiobjective optimization algorithm was employed to assess diseases severity and then produce individual treatment strategies. HF risk related parameters were screened and cataloged in six subclasses, i.e. cardiac structure, exercise tolerance, fluid overload, cardiac function, neural activity and electronic physiology. Accordingly, medication plans for individuals were determined. By linear weighting methods, a comprehensive index was generated to assess HF status of patients. The model was validated on 75 subjects. And the preliminary results demonstrated that the model was able to assess HF status and give treatment suggestions. In the term of agreement with the prescriptions given by physicians，the average accuracy of single drug suggested by the model was 91%. This work offered a helpful tool for facilitating individual HF treatment.
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