信号响应性基因载体及其应用研究

doi:10.3969/j.issn.0258-8021.2015.01.014

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Abstract The gene carrier is one of key factors for gene therapy. Although nonviral gene carriers have advantages in terms of their safety, the low transfection efficiency is still a major drawback for the research and therapeutic applications. In order to enhance the gene delivery efficiency and specific targeting ability, as well as to control their systematic and intracellular distribution, signal responsive nonviral carriers have been investigated and developed intensively, which can response to various physical, chemical, or biological signals. In this review, typical signal responsive gene carriers are introduced and classified into certain types according to the signal number and source. The latest progress of signal responsive carriers including their molecular structures, responding mechanisms, and biomedical applications are introduced in detail.

Key words： signal response stimulus responsive non viral gene carrier drug delivery systems

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	Wang Jing Liu Jian^#Xu Haiyan^#

Cite this article:

Wang Jing Liu Jian^#*Xu Haiyan^#*. Signal Response Gene Carriers[J]. journal1, 2015, 34(1): 99-108.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2015.01.014 OR http://cjbme.csbme.org/EN/Y2015/V34/I1/99

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