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| Application of Near-Infrared Fluorescence Photothermal Nanoparticles in Photothermal Therapy of Cervical Cancer |
| Zhu Lijun1,2#, Xiong Jiabao1,2, Du Zhong1,2, Ma Rong3, Zhang Xueliang2, Nuernisha Alifu1,2#* |
1(The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi 830054, China)
2(School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, China)
3(Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China) |
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Abstract Diagnosis and treatment of cervical cancer are of great significance to improve the survival rate and prognosis of patients. With the rapid development of nanomedicine in disease theranostics systems, near-infrared (NIR) fluorescence and photothermal therapy (PTT) based on fluorescent nanomaterials have provided promising solutions to improve the poor sensitivity, significant side effects and high incidence of postoperative metastasis in the diagnosis and treatment of cervical cancer. In this article, we reviewed the characteristics of bio-modified nanoparticles from NIR imaging and PTT, elaborated on the application of biologically modification new photothermal nanomaterials in the PTT of cervical cancer with the non-invasive, rapid, precise diagnosis and treatment, and low toxic side effects as the characteristic. Potentials of NIR imaging assisted PTT in preclinical research and clinical translation were discussed as well. Meanwhile, new NIR-photothermal nanoparticles and their preclinical experimental basis for translation to clinical treatment of cervical cancer were briefly introduced.
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Received: 05 July 2023
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Corresponding Authors:
*E-mail: 11530034@zju.edu.cn
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| About author:: #Member, Chinese Society of Biomedical Engineering |
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[1] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2] Naumann RW, Hollebecque A, Meyer T, et al. Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: results from the phase I/II checkmate 358 trial[J]. J Clin Oncol, 2019, 37(31): 2825-2834.
[3] Soni VD, Soni AN, Cervical cancer diagnosis using convolution neural network with conditional random field[C]//The Third International Conference on Inventive Research in Computing Applications (ICIRCA). New York: IEEE, 2021: 1749-1754.
[4] Stuebs FA, Gass P, Dietl AK, et al. Human papilloma virus genotype distribution in women with premalignant or malignant lesions of the uterine cervix[J]. Arch Gynecol Obstet, 2021, 304(3): 751-758.
[5] Rezqalla J, Alshatti M, Ibraheem A, et al. Human papillomavirus (HPV): unawareness of the causal role of HPV infection in cervical cancer, HPV vaccine availability, and HPV vaccine uptake among female schoolteachers in a middle eastern country[J]. J Infect Public Health, 2021, 14(5): 661-667.
[6] Hsu Yawen, Huang Ruilan, Su Pohsuan, et al. Genotype-specific methylation of HPV in cervical intraepithelial neoplasia[J]. J Gynecol Oncol, 2017, 28(4): e56.
[7] Hassan HE, Masaud H, Mohammed R, et al. Self-knowledge and body image among cervical cancer survivors′ women in Northern Upper Egypt[J]. Journal of Applied Health Sciences and Medicine, 2022, 1(1): 1-12.
[8] Jin Juebin, Zhu Haiyan, Teng Yingyan, et al. The accuracy and radiomics feature effects of multiple u-net-based automatic segmentation models for transvaginal ultrasound images of cervical cancer[J]. J Digit Imaging, 2022, 35(4): 983-992.
[9] Li Lei, Zhu Liren, Ma Cheng, et al. Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution[J]. Nat Biomed Eng, 2017, 1(5): 0071.
[10] Vinik Y, Ortega FG, Mills GB, et al. Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response[J]. Sci Adv, 2020, 6(40): eaba5714.
[11] Zeng Xiaxu, Zhang Xiaoan, Li Canyu, et al. Ultrahigh-resolution optical coherence microscopy accurately classifies precancerous and cancerous human cervix free of labeling[J]. Theranostics, 2018, 8(11): 3099-3110.
[12] Wei Junqiang, Liu Xinyue, Li Ting, et al. The new horizon of liquid biopsy in sarcoma: the potential utility of circulating tumor nucleic acids[J]. J Cancer, 2020, 11(18): 5293-5308.
[13] Kanniyappan U, Wang B, Yang C, et al. Performance test methods for near-infrared fluorescence imaging[J]. Med Phys, 2020, 47(8): 3389-3401.
[14] Song Xinyu, Han Xiaoyue, Yu Fabiao, et al. Polyamine-targeting gefitinib prodrug and its near-infrared fluorescent theranostic derivative for monitoring drug delivery and lung cancer therapy[J]. Theranostics, 2018, 8(8): 2217-2228.
[15] Shcherbakova DM, Baloban M, Emelyanov AV, et al. Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging[J]. Nat Commun, 2016, 7: 12405-12417.
[16] Shekhawat GS, Dudek SM, Dravid VP. Development of ultrasound bioprobe for biological imaging[J]. Sci Adv, 2017, 3(10): e1701176.
[17] Pal S, Ray A, Andreou C, et al. DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy[J]. Nat Commun, 2019, 10(1): 1926-1939.
[18] Jiang Ying, Lee HJ, Lan Lu, et al. Optoacoustic brain stimulation at submillimeter spatial precision[J]. Nat Commun, 2020, 11(1): 881-890.
[19] Tsai WK, Zettlitz KA, Tavaré R, et al. Dual-modality ImmunoPET/fluorescence imaging of prostate cancer with an anti-PSCA cys-minibody[J]. Theranostics, 2018, 8(21): 5903-5914.
[20] Dess RT, Sun Y, Jackson WC, et al. Association of presalvage radiotherapy PSA levels after prostatectomy with outcomes of long-term antiandrogen therapy in men with prostate cancer[J]. JAMA Oncol, 2020, 6(5): 735-743.
[21] Xu Dazhuang, Li Lei, Chu Chengchao, et al. Advances and perspectives in near-infrared fluorescent organic probes for surgical oncology[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020, 12(5): e1635.
[22] Grossi M, Morgunova M, Cheung S, et al. Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time[J]. Nat Commun, 2016, 7: 10855.
[23] Sanchez-Casanova S, Martin-Saavedra FM, Escudero-Duch C, et al. Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration[J]. Biomaterials, 2020, 241: 119909.
[24] Nam J, Son S, Ochyl LJ, et al. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer[J]. Nat Commun, 2018, 9(1): 1074-1087.
[25] Zhou Yun, Sun Xuanzi, Zhou Liansuo, et al. pH-sensitive and long-circulation nanoparticles for near-infrared fluorescence imaging-monitored and chemo-photothermal synergistic treatment against gastric cancer[J]. Front Pharmacol, 2020, 11: 610883.
[26] Wang Xue, Liu Shi, Guan Yuyao, et al. Vaginal drug delivery approaches for localized management of cervical cancer[J]. Advanced Drug Delivery Reviews, 2021, 174: 114-126.
[27] Ma Lingling, Zhou Yanying, Zhang Zhaowenbin, et al. Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair[J]. Sci Adv, 2020, 6(32): eabb1311.
[28] Carattino A, Caldarola M, Orrit M. Gold nanoparticles as absolute nanothermometers[J]. Nano Lett, 2018, 18(2): 874-880.
[29] Geada IL, Ramezani-Dakhel H, Jamil T, et al. Insight into induced charges at metal surfaces and biointerfaces using a polarizable Lennard-Jones potential[J]. Nat Commun, 2018, 9(1): 716-730.
[30] Xu Yue, Li Hua, Fan Lixue, et al. Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs[J]. J Adv Res, 2020, 28: 165-174.
[31] Fan Xi, Yuan Zeting, Shou Chenting, et al. cRGD-conjugated Fe3O4@PDA-DOX multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy[J]. Int J Nanomedicine, 2019, 14: 9631-9645.
[32] Hussein EA, Zagho MM, Rizeq BR, et al. Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene[J]. Int J Nanomedicine, 2019, 14: 4529-4539.
[33] Lin Fangchu, Hsu CH, Lin Yungyang. Nano-therapeutic cancer immunotherapy using hyperthermia-induced heat shock proteins: insights from mathematical modeling[J]. Int J Nanomedicine, 2018, 13: 3529-3539.
[34] Shen Yan, Xia Yun, Yang Ershuang, et al. A polyoxyethylene sorbitan oleate modified hollow gold nanoparticle system to escape macrophage phagocytosis designed for triple combination lung cancer therapy via LDL-R mediated endocytosis[J]. Drug Deliv, 2020, 27(1): 1342-1359.
[35] Han HS, Choi KY. Advances in nanomaterial-mediated photothermal cancer therapies: toward clinical applications[J]. Biomedicines, 2021, 9(3): 305-320.
[36] Lv Shibo, Miao Yuyang, Liu Dapeng, et al. Recent development of photothermal agents (PTAs) based on small organic molecular dyes[J]. Chembiochem, 2020, 21(15): 2098-2110.
[37] Younis MR, He G, Qu Junle, et al. Inorganic nanomaterials with intrinsic singlet oxygen generation for photodynamic therapy[J]. Adv Sci (Weinh), 2021, 8(21): e2102587.
[38] Park JM, Choi HE, Kudaibergen D, et al. Recent advances in hollow gold nanostructures for biomedical applications[J]. Frontiers in Chemistry, 2021, 9: 699284.
[39] Cheng Qian, Gao Fan, Yu Wuyang, et al, Near-infrared triggered cascade of antitumor immune responses based on the integrated core–shell nanoparticle[J]. Advanced Functional Materials, 2020, 30(50): 2000335.
[40] Lee SY, Shieh MJ. Platinum(II) drug-loaded gold nanoshells for chemo-photothermal therapy in colorectal cancer[J]. ACS Appl Mater Interfaces, 2020, 12(4): 4254-4264.
[41] He Huamei, Liu Lanlan, Zhang Shengping, et al. Smart gold nanocages for mild heat-triggered drug release and breaking chemoresistance[J]. J Control Release, 2020, 323: 387-397.
[42] Hasanzadeh Kafshgari M, Agiotis L, Largillière I, et al. Antibody-functionalized gold nanostar-mediated on-resonance picosecond laser optoporation for targeted delivery of RNA therapeutics[J]. Small, 2021, 17(19): e2007577.
[43] Liu Ping, Wang Yidan, Liu Yang, et al. S-nitrosothiols loaded mini-sized Au@silica nanorod elicits collagen depletion and mitochondrial damage in solid tumor treatment[J]. Theranostics, 2020, 10(15): 6774-6789.
[44] Gao Renxi, Chen Jinjing, Fan Guanghua, et al . Optical properties of formation of gold nanoparticle aggregates deposited on quartz glass and application to SPR sensing[J]. Optical Materials, 2022, 125:112104.
[45] Chellamuthu P, Tran F, Silva KPT, et al. Engineering bacteria for biogenic synthesis of chalcogenide nanomaterials[J]. Microb Biotechnol, 2019, 12(1): 161-172.
[46] He Yuchu, Cong Cong, Li Xiaoling, et al. Nano-drug system based on hierarchical drug release for deep localized/systematic cascade tumor therapy stimulating antitumor immune responses[J]. Theranostics, 2019, 9(10): 2897-2909.
[47] Tyagi H, Kushwaha A, Kumar A, et al. A facile pH controlled citrate-based reduction method for gold nanoparticle synthesis at room temperature[J]. Nanoscale research letters, 2016, 11(1): 1-11.
[48] Guerrero-Florez V, Mendez-Sanchez SC, Patrón-Soberano, OA, et al. Gold nanoparticle-mediated generation of reactive oxygen species during plasmonic photothermal therapy: a comparative study for different particle sizes, shapes, and surface conjugations[J]. Journal of Materials Chemistry B, 2020, 8(14): 2862-2875.
[49] Rajkumar S, Prabaharan M. Multi-functional FITC-silica@ gold nanoparticles conjugated with guar gum succinate, folic acid and doxorubicin for CT/fluorescence dual imaging and combined chemo/PTT of cancer[J]. Colloids and Surfaces B: Biointerfaces, 2020, 186: 110701.
[50] Zheng Tao, Wang Wentao, Wu Fan. et al. Zwitterionic polymer-gated Au@ TiO2 core-shell nanoparticles for imaging-guided combined cancer therapy[J]. Theranostics, 2019, 9(17): 5035-5048.
[51] Tong Xiao, Wang Zhantong, Sun Xiaolian, et al. Size dependent kinetics of gold nanorods in EPR mediated tumor delivery[J]. Theranostics, 2016, 6(12): 2039-2051.
[52] Bloise N, Massironi A, Della Pina C, et al. Extra-small gold nanospheres decorated with a thiol functionalized biodegradable and biocompatible linear polyamidoamine as nanovectors of anticancer molecules[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8: 132-152.
[53] Liu Yanlei, Zhi Xiao, Yang Meng, et al, Tumor-triggered drug release from calcium carbonate-encapsulated gold nanostars for near-infrared photodynamic/photothermal combination antitumor therapy[J]. Theranostics, 2017, 7(6): 1650-1662.
[54] Mioc M, Pavel IZ, Ghiulai R, et al. The cytotoxic effects of betulin-conjugated gold nanoparticles as stable formulations in normal and melanoma cells[J]. Frontiers in Pharmacology, 2018, 9: 429-445.
[55] Curcio A, Silva AKA, Cabana S, et al. Iron oxide nanoflowers @ CuS hybrids for cancer tri-therapy: interplay of photothermal therapy, magnetic hyperthermia and photodynamic therapy[J]. Theranostics, 2019, 9(5): 1288-1302.
[56] Wang Limei, Pei Jin, Cong Zhangcheng, et al. Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumor-bearing mice[J]. Int J Nanomedicine, 2019, 14: 1817-1833.
[57] Xu Weijun, Qian Junmin, Hou Guanghui, et al. A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer[J]. Acta Biomater, 2019, 83: 400-413.
[58] Chakraborty R, Leshem-Lev D, Kornowski R, et al. The scattering of gold nanorods combined with differential uptake, paving a new detection method for macrophage subtypes using flow cytometery[J]. Nano Lett, 2020, 20(11): 8360-8368.
[59] Liu Yanling, Tan Manman, Zhang Yujuan, et al. Targeted gene silencing BRAF synergized photothermal effect inhibits hepatoma cell growth using new GAL-GNR-siBRAF nanosystem[J]. Nanoscale Res Lett, 2020, 15(1): 116-128.
[60] El Hadri H, Gigault J, Tan J, et al. An assessment of retention behavior for gold nanorods in asymmetrical flow field-flow fractionation[J]. Anal Bioanal Chem, 2018, 410(27): 6977-6984.
[61] Singh P, Pandit S, Mokkapati VRSS, et al. Gold nanoparticles in diagnostics and therapeutics for human cancer[J]. Int J Mol Sci, 2018, 19(7): 1979-1995.
[62] Zhang Linxue, Chen Shuang, Ma Rong, et al. NIR-excitable PEG-modified Au nanorods for photothermal therapy of cervical cancer[J]. ACS Applied Nano Materials, 2021, 4(12): 13060-13070.
[63] Lee C, Kwon W, Beack S, et al. Biodegradable nitrogen-doped carbon nanodots for non-invasive photoacoustic imaging and photothermal therapy[J]. Theranostics, 2016, 6(12): 2196-2208.
[64] Agabeigi R, Rasta SH, Rahmati-Yamchi M, et al. Novel chemo-photothermal therapy in breast cancer using methotrexate-loaded folic acid conjugated Au@SiO2 nanoparticles[J]. Nanoscale Res Lett, 2020, 15(1): 62-76.
[65] Huang Shuanghui, Peng Si, Wang Qiuyue, et al. Gold nanorods conjugated with biocompatible zwitterionic polypeptide for combined chemo-photothermal therapy of cervical cancer[J]. Colloids Surf B Biointerfaces, 2021, 207: 112014.
[66] Huang Xuan, Wu Shanshan, Du Xuezhong. Gated mesoporous carbon nanoparticles as drug delivery system for stimuli-responsive controlled release[J] Carbon, 2016, 101: 135-142.
[67] Xu Guiju, Liu Shengju, Niu Huan, et al. Functionalized mesoporous carbon nanoparticles for targeted chemo-photothermal therapy of cancer cells under near-infrared irradiation[J]. RSC advances, 2014, 4(64): 33986-33997.
[68] Fang Junfeng, Liu Yanqing, Chen Yiwen, et al. Graphene quantum dots-gated hollow mesoporous carbon nanoplatform for targeting drug delivery and synergistic chemo-photothermal therapy[J]. Int J Nanomedicine, 2018, 4(13): 5991-6007.
[69] Wu Fan, Zhang Ming, Lu Hanwen, et al. Triple stimuli-responsive magnetic hollow porous carbon-based nanodrug delivery system for magnetic resonance imaging-guided synergistic photothermal/chemotherapy of cancer[J]. ACS Appl Mater Interfaces, 2018, 10(26): 21939-21949.
[70] Chen Shuang, Zhu Lijun, Du Zhong, et al. Polymer encapsulated clinical ICG nanoparticles for enhanced photothermal therapy and NIR fluorescence imaging in cervical cancer[J]. RSC Adv, 2021, 11(34): 20850-20858.
[71] Ma Rong, Alifu N, Du Zhong, et al. Indocyanine green-based theranostic nanoplatform for NIR fluorescence image-guided chemo/photothermal therapy of cervical cancer[J]. Int J Nanomedicine, 2021, 16: 4847-4861.
[72] Zhu Lijun, Chen Jianjun, Yan Ting, et al. Near-infrared emissive polymer-coated IR-820 nanoparticles assisted photothermal therapy for cervical cancer cells[J]. J Biophotonics, 2021, 14(11): e202100117.
[73] Du Zhong, Ma Rong, Chen Shuang, et al. A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer[J]. Nanoscale Adv, 2022, 4(18): 4016-4024.
[74] Huang Shengnan, Li Chunming, Wang Weiping, et al. A54 peptide-mediated functionalized gold nanocages for targeted delivery of DOX as a combinational photothermal-chemotherapy for liver cancer[J]. Int J Nanomedicine, 2017, 12: 5163-5176.
[75] Wang Sijia, Xin Jing, Zhang Luwei, et al. Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells[J]. Int J Nanomedicine, 2018, 13: 2143-2160.
[76] Zhang Guobing, Ma Suxiang, Wang Weiwei, et al. Aza-based donor-acceptor conjugated polymer nanoparticles for near-infrared modulated photothermal conversion[J]. Front Chem, 2019, 7: 359-369.
[77] Yao Qing, Lan Qinghua, Jiang Xinyu, et al. Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing[J]. Theranostics, 2020, 10(25): 11719-11736.
[78] Pan Houhe, Li Shukun, Kan Jinglan, et al. A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation[J]. Chem Sci, 2019, 10(35): 8246-8252.
[79] Fan Huimin, Chen Shuang, Du Zhong, et al, New indocyanine green therapeutic fluorescence nanoprobes assisted high-efficient photothermal therapy for cervical cancer[J]. Dyes and Pigments, 2022, 200: 110174-110186.
[80] Choi S, Lee SH, Park S, et al. Indocyanine green-loaded PLGA nanoparticles conjugated with hyaluronic acid improve target specificity in cervical cancer tumors[J]. Yonsei Med J, 2021, 62(11): 1042-1051.
[81] Nanashima A, Hiyoshi M, Imamura N, et al. Recent advances in photodynamic imaging and therapy in hepatobiliary malignancies: clinical and experimental aspects[J]. Curr Oncol, 2021, 28(5): 4067-4079.
[82] Yannuzz LA. Indocyanine green angiography: a perspective on use in the clinical setting[J]. American Journal of Ophthalmology, 2011, 151(5): 745-751.
[83] Hirohashi K, Anayama T, Wada H, et al. Lung cancer photothermal ablation by low-power near-infrared laser and topical injection of indocyanine green[J]. Interact Cardiovasc Thorac Surg, 2019, 29(5): 693-698.
[84] Jung E, Lee J, Jeong L, et al. Stimulus-activatable echogenic maltodextrin nanoparticles as nanotheranostic agents for peripheral arterial disease[J]. Biomaterials, 2019, 192: 282-291.
[85] Chen Qian, Xu Ligeng, Liang Chao, et al. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy[J]. Nat Commun, 2016, 7: 13193-13206.
[86] Liu Bei, Li Chunxia, Chen Guanying, et al. Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/chemotherapy triggered by 808 nm laser[J]. Adv Sci, 2017, 4(8): 1600540-1600552.
[87] Du Qian, Qin Xiaohan, Zhang Mengzhu, et al. A mitochondrial-metabolism-regulatable carrier-free nanodrug to amplify the sensitivity of photothermal therapy[J]. Chem Commun, 2021, 57(71): 8993-8996.
[88] Jiang Yue, Huang Chunzhi, Luan Yuxia. Lactosylated IR820/DOX co-assembled nanodrug for synergetic antitumour therapy[J]. International Journal of Nanomedicine, 2020, 15: 4431-4441.
[89] Rampa DR, Ko C, Lee Y, et al. NIR dye-conjugated maltodextrin for photothermal therapy of cancer[J]. Macromolecular Research, 2021, 29(4): 306-312.
[90] Huang Kaizong, Gao Mengyue, Fan Lin, et al. IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer[J]. Biomater Sci, 2018, 6(11): 2925-2931.
[91] Lei Tingjun, Fernandez-Fernandez A, Manchanda R, et al. Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating[J]. Beilstein J Nanotechnol, 2014, 5: 313-322.
[92] Alifu N, Dong Xiaobiao, Li Dongyu, et al. Aggregation-induced emission nanoparticles as photosensitizer for two-photon photodynamic therapy[J]. Materials Chemistry Frontiers, 2017, 1(9): 1746-1753.
[93] Liu Leijing, Liu Wen, Ji Guang, et al. NIR emission nanoparticles based on FRET composed of AIE luminogens and NIR dyes for two-photon fluorescence imaging[J]. Chinese Journal of Polymer Science, 2019, 37(4): 401-408.
[94] Yan Ting, Alimu G, Zhu Lijun, et al. PpIX/IR-820 dual-modal therapeutic agents for enhanced PDT/PTT synergistic therapy in cervical cancer[J]. ACS Omega, 2022, 7(49): 44643-44656. |
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