基于改进的视觉CPT范式对注意缺陷多动障碍患儿额区ERPs的研究

doi:10.3969/j.issn.0258-8021. 2014. 04.01

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Abstract The eventrelated potentials (ERPs) coming from children who were diagnosed as attentiondeficit hyperactivity disorder (ADHD) were analyzed in this paper, aiming to investigate the neural activity in the frontal lobe, when the children performed a selective attention task. A high density electroencephalogram (EEG) acquisition instrument was utilized to record the ERPs of subjects and an improved visual continuous performance test (Visual-CPT) was used as the experimental paradigm. Twelve diseased children (ADHD group) and 13 healthy children (Control group) participated the experiment. The behavior and ERPs results were analyzed and compared with a twosample Ttest between two groups under Go and No-go conditions. Results show that: 1) The ADHD group performed a poor task in the current study, with a higher missing rate and false alarm rate as well as a longer reaction time than control group; 2) Under both Go and No-go conditions, there were no significant difference observed in the ERPs latency. However, comparing with the control group, ADHD group has a lower N2 amplitude in frontal region (P<0.05); 3) In addition, the ADHD group show a higher P2 amplitude under the condition of No-go (P<0.05). The result indicates that children with ADHD have a disorder in cognitive function implementation, and this impairment may be associated with the abnormal ERPs amplitudes in frontal lobe.

Key words： eventedrelated potentials (ERPs) attentiondeficit hyperactivity disorder (ADHD) visualcontinuous performance test (VisualCPT) executive disorder

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	WAN Xiao Jiao¹WANG SuHong²GAO Xiao Rong^3#YAN Zheng^1*

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WAN Xiao Jiao¹WANG SuHong²GAO Xiao Rong^3#YAN Zheng^1*. The Study on Frontal ERPs Based upon Improved Visual CPT Paradigm in Children with Attention Deficit Hyperactivity Disorder[J]. journal1, 2014, 33(4): 385-391.

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http://cjbme.csbme.org/EN/ 10.3969/j.issn.0258-8021. 2014. 04.01 OR http://cjbme.csbme.org/EN/Y2014/V33/I4/385

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