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The Study on Frontal ERPs Based upon Improved Visual CPT Paradigm in Children with Attention Deficit Hyperactivity Disorder |
1 School of Information Science and Engineering, Huaqiao University, Xiamen 361021, China
2 Department of Neuroscience, The Third Affiliated Hospital of Soochow University, Suzhou 213003, China
3 Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China |
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Abstract The eventrelated potentials (ERPs) coming from children who were diagnosed as attentiondeficit hyperactivity disorder (ADHD) were analyzed in this paper, aiming to investigate the neural activity in the frontal lobe, when the children performed a selective attention task. A high density electroencephalogram (EEG) acquisition instrument was utilized to record the ERPs of subjects and an improved visual continuous performance test (Visual-CPT) was used as the experimental paradigm. Twelve diseased children (ADHD group) and 13 healthy children (Control group) participated the experiment. The behavior and ERPs results were analyzed and compared with a twosample Ttest between two groups under Go and No-go conditions. Results show that: 1) The ADHD group performed a poor task in the current study, with a higher missing rate and false alarm rate as well as a longer reaction time than control group; 2) Under both Go and No-go conditions, there were no significant difference observed in the ERPs latency. However, comparing with the control group, ADHD group has a lower N2 amplitude in frontal region (P<0.05); 3) In addition, the ADHD group show a higher P2 amplitude under the condition of No-go (P<0.05). The result indicates that children with ADHD have a disorder in cognitive function implementation, and this impairment may be associated with the abnormal ERPs amplitudes in frontal lobe.
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