难治性幻听精神分裂症患者静息态脑电特异性特征分析

doi:10.3969/j.issn.0258-8021.2023.05.001

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Abstract Schizophrenia is a heavy mental disease that seriously harms human physical and mental health. Auditory hallucination is one of core symptoms for schizophrenia, about 30% of patients with auditory hallucinations cannot be cured by drug treatment, called refractory auditory hallucinations (RAH). In order to explore the formation mechanism of refractory auditory hallucinations and the characteristics of their brain activity, 30 patients with refractory auditory hallucinations and 30 patients with non-refractory auditory hallucinations (NRAH) were enrolled. In this study, the 8-minute resting paradigm with eyes open and closed was adopted, and 64 channels of EEG (electroencephalography) data was collected at the same time. Then the absolute power spectrum of six frequency bands and the distribution of cortical EEG of the two groups were calculated by power spectrum and source localization analysis. Experimental results showed that the δ band was more activated in the right superior temporal gyrus, middle temporal gyrus, superior temporal sulcus and angular gyrus in RAH than in NRAH, but the average power of whole brain was significantly lower than that of NRAH group (p(RAH)=64.05±116.82, p(NRAH)=110.40±125.56, P<0.01). The absolute power of low-γ (p(RAH)=7.14±14.88, p(NRAH)= 8.99±10.13, P<0.05) and high-γ (p(RAH)=11.46±17.48, p(NRAH)=30.12±46.88, P<0.01) was significantly lower than that of NRAH, and the intensity and range of activation of them in the middle temporal gyrus, superior temporal to temporoparietal lobe, and frontoparietal junction were lower than those in NRAH, and the phenomenon of lateralization was absent in NRAH. In conclusion, δ, low-γ and high-γ may be potential physiological indicators of refractory auditory hallucinations, and the formation mechanism of refractory auditory hallucinations may be related to the overactivation of slow waves (especially δ) in the temporal lobe and the inactivation of high-frequency oscillations (especially γ) in the temporal lobe. The results of this study can provide effective objective basis for exploring the brain activity characteristics of patients with refractory auditory hallucinations and the disease mechanism of refractory auditory hallucinations, which has certain theoretical significance and clinical value.

Key words： resting-state EEG schizophrenia auditory hallucinations absolute power spectrum source localization

Received: 25 July 2022

PACS:

R318

Corresponding Authors: ^*E-mail: richardming@tju.edu.cn

About author:: ^#Member, Chinese Society of Biomedical Engineering

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	Liu Shuang
	Liao Jingmeng
	Wang Xiaojuan
	Li Meijuan
	Gao Ying
	Li Jie
	Ming Dong

Cite this article:

Liu Shuang,Liao Jingmeng,Wang Xiaojuan, et al. Analysis of Resting-State EEG Specific Characteristics in Schizophrenic with
RefractoryAuditory Hallucination[J]. Chinese Journal of Biomedical Engineering, 2023, 42(5): 513-519.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2023.05.001 OR http://cjbme.csbme.org/EN/Y2023/V42/I5/513

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