基于MRI的精神分裂症阴性症状脑影像研究进展

doi:10.3969/j.issn.0258-8021.2022.01.012

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Abstract Patients with chronic schizophrenia have negative symptoms as the main clinical manifestations, which are also the main factor of mental disability, has a great effect on the life quality of patients. So far, the neural mechanism of negative symptoms is still unclear, making it hard to be controlled. This article reviewed the research progress in different aspects in this field, including the occurrence of schizophrenia associated to the damage of subcortical regions (the striatum and thalamus), and the abnormality of the subcortex-cortical connectivity associated to negative symptoms. This article also proposed the perspectives of the new method (reconstruction of topological brain connection) in the study of the mechanism of negative symptoms of schizophrenia, such as exploring the coupling of the dopaminergic neurotransmitter system of the striatum-thalamus-prefrontal loop, and the deconstruction of spatial distribution information. In addition, the application of deep learning can further decode the topological features of the critical brain connections relate to negative symptoms, which is expected to become a potentially approach to explore the mechanism of negative symptoms of schizophrenia.

Key words： schizophrenia brain connectome thalamus striatum mental symptoms

Received: 23 September 2020

PACS:

R318

Corresponding Authors: ^* E-mail: chengluo@uestc.edu.cn

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	Articles by authors
	Gong Jinnan
	Yang Zhuoru
	Li Lu
	Jiang Yuchao
	Dong Debo
	Shao Junming
	Yao Dezhong
	Luo Cheng

Cite this article:

Gong Jinnan,Yang Zhuoru,Li Lu, et al. Neuroimaging Research Progress of Negative Symptoms in Schizophrenia[J]. Chinese Journal of Biomedical Engineering, 2022, 41(1): 108-113.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2022.01.012 OR http://cjbme.csbme.org/EN/Y2022/V41/I1/108

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