铁离子-单宁酸处理增强牛颈静脉综合性能

doi:10.3969/j.issn.0258-8021.2023.03.009

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Abstract Glutaraldehyde (GA) cross-linked bovine jugular vein (BJV) is prone to calcification, which affects its wide clinical application. The addition of tannic acid (TA) treatment in combination with GA cross-linking has achieved excellent anti-calcification effect, however, with a deficiency of poor tissue compliance. As tannins can chelate with metal cations, this study used ferric ions (Fe³⁺) to interact with tannins to improve the comprehensive performance of TA treated BJV. In this study, the addition schemes of Fe³⁺ and reaction conditions such as pH were explored, the mechanical properties were examined by the uniaxial tensile test, the rat subcutaneous implantation model was used to determine the calcification level, and two-point bending method was used to test the flexibility. Vessels obtained from optimized treatment protocols were tested for biocompatibility. The results showed that under pH=8, the addition of Fe³⁺ before TA treatment improved the tissue compliance, and the flexibility was significantly improved compared with that of TA group, meanwhile, the mechanical strength was maintained. Calcium contents after subcutaneous implantation in rats were significantly lower than that in GA group [21d:(1.71±0.41) mg/g vs (38.12±7.40) mg/g, 60d:(2.73±1.13) mg/g vs(124.19±14.22) mg/g, P<0.05], and were equal to that of TA group (P>0.05). Moreover, the biocompatibility of theBJV met the requirements of implantable medical devices. This TA-Fe³⁺ treatment scheme is expected to be a new method for anti-calcification of BJV.

Key words： bovine jugular vein tannic acid ferric chloride anti-calcification biocompatibility

Received: 02 July 2022

PACS:

R318

Corresponding Authors: ^* E-mail: zhoujy@263.net

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	Articles by authors
	Wang Aili
	Zhou Jianye
	Wang De
	Zhou Qingliang
	Wang Yumiao
	Huo Meijun
	Wang Yibo

Cite this article:

Wang Aili,Zhou Jianye,Wang De, et al. Ferric Chloride and Tannic Acid Treatment Enhance the Comprehensive Properties of Bovine Jugular Vein[J]. Chinese Journal of Biomedical Engineering, 2023, 42(3): 328-335.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2023.03.009 OR http://cjbme.csbme.org/EN/Y2023/V42/I3/328

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