导尿管表面局麻药物缓释涂层的形成及其镇痛效果研究

doi:10.3969/j.issn.0258-8021.2021.06.08

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Abstract Catheterization, especially the indwelling of urinary catheter may cause severe discomfort and pain in the patients, while the clinical approaches can only relieve the uncomfortable symptoms in a very short time. Therefore, this research has developed a technology that can simply and conveniently form a long-term release coating of local anesthetics on the surface of the catheter to achieve long-term anesthesia effects of indwelling catheters. In this study, polyvinyl alcohol, poloxamer 407, and lidocaine were blended as a film-forming liquid to form a film on the surface of the catheter (LID-P407-PVA), and the final sustained-release drug film was flat, with appropriate thickness and good wettability. Thein vitro release results showed that LID-P407-PVA can continuously release lidocaine in water for up to 48 h. The mouse model of pain caused by heat stimulation (n ≥ 5) was used to evaluate the analgesic effect of LID-P407-PVA in vivo. The results showed that the implantation of LID-P407-PVA next to the mouse sciatic nerve can produce significant sensory block for more than 20 h. Besides, it had a significant prolongation compared with the free drug group, showing a good sustained analgesic effect in vivo. The histopathological evaluation of the implantation site after the operation showed that the histocompatibility of LID-P407-PVA was good.

Key words： urinary catheter lidocaine polyvinyl alcohol poloxamer sustained release film

Received: 19 April 2021

PACS:

R318

About author:: ^#Member, Chinese Society of Biomedical Engineering

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	Lai Xinning
	Xiao Bo
	Huang Yuguang
	Xu Haiyan
	Xu Li
	Liu Jian

Cite this article:

Lai Xinning,Xiao Bo,Huang Yuguang, et al. The Formation of Coating Film on the Surface of Urinary Catheter for Sustained-Release of Local Anesthetic and its Analgesic Effect[J]. Chinese Journal of Biomedical Engineering, 2021, 40(6): 712-718.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2021.06.08 OR http://cjbme.csbme.org/EN/Y2021/V40/I6/712

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