The Formation of Coating Film on the Surface of Urinary Catheter for Sustained-Release of Local Anesthetic and its Analgesic Effect
Lai Xinning1, Xiao Bo2, Huang Yuguang2, Xu Haiyan1#, Xu Li2*, Liu Jian1#*
1(Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China) 2(Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China)
Abstract Catheterization, especially the indwelling of urinary catheter may cause severe discomfort and pain in the patients, while the clinical approaches can only relieve the uncomfortable symptoms in a very short time. Therefore, this research has developed a technology that can simply and conveniently form a long-term release coating of local anesthetics on the surface of the catheter to achieve long-term anesthesia effects of indwelling catheters. In this study, polyvinyl alcohol, poloxamer 407, and lidocaine were blended as a film-forming liquid to form a film on the surface of the catheter (LID-P407-PVA), and the final sustained-release drug film was flat, with appropriate thickness and good wettability. Thein vitro release results showed that LID-P407-PVA can continuously release lidocaine in water for up to 48 h. The mouse model of pain caused by heat stimulation (n ≥ 5) was used to evaluate the analgesic effect of LID-P407-PVA in vivo. The results showed that the implantation of LID-P407-PVA next to the mouse sciatic nerve can produce significant sensory block for more than 20 h. Besides, it had a significant prolongation compared with the free drug group, showing a good sustained analgesic effect in vivo. The histopathological evaluation of the implantation site after the operation showed that the histocompatibility of LID-P407-PVA was good.
Lai Xinning,Xiao Bo,Huang Yuguang, et al. The Formation of Coating Film on the Surface of Urinary Catheter for Sustained-Release of Local Anesthetic and its Analgesic Effect[J]. Chinese Journal of Biomedical Engineering, 2021, 40(6): 712-718.
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