经颅磁声电刺激对大鼠工作记忆局部场电位gamma节律的影响

doi:10.3969/j.issn.0258-8021.2021.05.04

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Abstract Transcranial magneto-acoustic-electrical stimulation (TMAES) is a new non-invasive neural regulation technique, which uses ultrasound and static magnetic field to generate an induction electric field to regulate the oscillating activities of the corresponding brain regions, thus affecting cognitive functions such as learning and memory. The purpose of this study was to investigate the effects of TMAES on the oscillations of gamma rhythmic nerve during the working memory (WM) behavior experiment in rats. Twenty healthy adult Wistar rats were divided into control group and stimulation group. The stimulation group received TMAES of 0.05～0.15 T and 1.33～13.33 W/cm² for 10 days, while the control group didn′t accept any stimulations. The local field potentials (LFPs) in the prefrontal cortex (PFC) of the two groups of rats were recorded during the T-maze working memory task, and the behavioral differences, time-frequency distribution of the local field potential and correlation of mutual information between the two groups of rats were compared and analyzed. The experimental results showed that the time required for the rats in the stimulation group to perform the working memory task to achieve the correct rate above 80% was (7.57±0.99) d, which was significantly less than (10.65±2.32) d in the control group (P<0.05). Before and after passing through the behavioral selection position, the energy density of gamma band of local field potential signal in 2.66～13.33 W/cm² group and 0.10～0.15 T group was significantly higher than that in the control group (P<0.05). The correlation between the 12 channel signals of the gamma band of rats in 6.65～13.33 W/cm² group and 0.10～0.15 T group was significantly stronger than that in the control group (P<0.05). The results indicated that the transcranial magneto-acoustic-electrical stimulation could enhance the rhythmic oscillating activity of prefrontal cortex neurons in working memory of rats, which lays a foundation for exploring the mechanism of TMAES regulating brain memory function.

Key words： transcranial magneto-acoustic-electrical stimulation working memory local field potentials gamma rhythm

Received: 06 May 2021

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R318

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	Articles by authors
	Zhang Shuai
	Dang Junwu
	Jiao Lipeng
	Wu Jiankang
	Wang Yixiao
	Xu Guizhi

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Zhang Shuai,Dang Junwu,Jiao Lipeng, et al. Effects of Transcranial Magneto-Acoustic-Electrical Stimulation on Gamma Rhythm of Local Field Potentials during Working Memory Task of Rats[J]. Chinese Journal of Biomedical Engineering, 2021, 40(5): 540-549.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2021.05.04 OR http://cjbme.csbme.org/EN/Y2021/V40/I5/540

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