深部脑刺激的逆向激活效应及其研究进展

doi:10.3969/j.issn.0258-8021.2021.03.12

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Abstract Deep brain stimulation (DBS) is an effective treatment for movement disorders, which is also a common tool for probing the function of neural circuits. Although the therapeutic efficacy of DBS has already been demonstrated in clinics, the precise mechanisms of its action still remain largely unclear, which limits the further development, optimization, and application of this technology. Electrophysiological experiments and computational models indicate DBS preferentially activates the axons and presynaptic terminals, and the resulting axonal spikes stimulate the cell body and dendrites of target cells as well as the upstream and downstream nuclei through inducing antidromic activation, orthodromic activation, and neurotransmitter release. The fibers projecting to the target nuclei exhibit complex branching structures, which enables the antidromic activation to be an important cellular mechanism underlying the widespread effects of DBS on multiple anatomical structures. Particularly, antidromic activation contributes to the understanding of microscopic, mesoscopic, and macroscopic effects of DBS. In this paper, we first summarized the general cellular principles of action of DBS, and mainly introduced the stimulus-induced antidromic activation. Then, we presented an exhaustive review on the main findings of antidromic activation pattern in recent years, and discussed the implications of antidromic activation for understanding the effects of DBS. Finally, we raised several key issues on the antidromic activation that need to be addressed in the future.

Key words： deep brain stimulation(DBS) antidromic activation axon presynaptic terminals

Received: 09 September 2020

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R318

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	Yi Guosheng
	Jiao Lifeng
	Wang Jiang
	Wei Xile

Cite this article:

Yi Guosheng,Jiao Lifeng,Wang Jiang, et al. Recent Advances on Antidromic Activation of Deep Brain Stimulation[J]. Chinese Journal of Biomedical Engineering, 2021, 40(3): 364-374.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2021.03.12 OR http://cjbme.csbme.org/EN/Y2021/V40/I3/364

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