大鼠海马神经元群体对于高频电刺激的响应

doi:10.3969/j.issn.0258-8021. 2014. 02.008

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Abstract Deep brain stimulations (DBS) have been developed for treating brain diseases such as Parkinson’s disease and epilepsy. But the mechanisms underlying DBS are not clear yet. In order to study the effects of DBS on the neural networks of brain, both orthodromic and antidromichigh frequency stimulation (HFS) were respectively applied on afferent fibers and efferent fibers of the hippocampal CA1 region in anaesthetized rats. Synchronized firings of neuronal action potential (i.e., population spike, PS) of CA1 pyramidal cells were examined. Results showed that 50 Hz orthodromicHFS induced persistent PS firings, while 100 and 200 Hz orthodromicHFS induced much less PS firings. During antidromicHFS with different frequencies, every stimulation pulse evoked a PS. However, the PS amplitude decreased gradually. The decrease of PS amplitude was more rapid with higher stimulation frequency. Taken together, the HFS of axons has excitatory effects on the neuronal populations both upstream and downstream. But the higher the stimulation frequency is, the less the excitatory effect is. These results are important for the further understanding of DBS mechanisms and for the safe and effective application of DBS in clinic.

Key words： deep brain stimulation high frequency stimulation hippocampus population spike neural network

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	FENG Zhou Yan^*YU Ying CAO Jia Yue GUO Zhe Shan

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FENG Zhou Yan^*YU Ying CAO Jia Yue GUO Zhe Shan. Response of Neuronal Population to High Frequency Electrical Stimulation in Rat Hippocampus[J]. journal1, 2014, 33(2): 186-193.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014. 02.008 OR http://cjbme.csbme.org/EN/Y2014/V33/I2/186

［1］Hamani C, Andrade D, Hodaie M, et al. Deep brain stimulation for the treatment of epilepsy ［J］. Int J Neural Syst, 2009, 19(3): 213-226.
［2］Kuhn J, Mller M, Müller U, et al. Deep brain stimulation for the treatment of addiction ［J］. Addiction, 2011, 106(8): 1536-1537.
［3］Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatmentresistant depression ［J］. Neuron, 2005, 45(5): 651-660.
［4］Boon P, Vonck K, De Herdt V, et al. Deep brain stimulation in patients with refractory temporal lobe epilepsy［J］. Epilepsia, 2007, 48(8): 1551-1560.
［5］Jobst B. Brain stimulation for surgical epilepsy［J］. Epilepsy Res, 2010, 89(1): 154-161.
［6］Bragin A, Penttonen M, Buzsaki G. Termination of epileptic afterdischarge in the hippocampus ［J］. J Neurosci, 1997, 17(7): 2567-2579.
［7］Lee HW, Webber WR, Crone N, et al. When is electrical cortical stimulation more likely to produce afterdischarges［J］? Clin Neurophysiol, 2010, 121(1):14-20.
［8］Gwinn RP, Spencer DD. Fighting fire with fire: brain stimulation for the treatment of epilepsy ［J］. Clin Neurosci Res, 2004, 4(1): 95-105.
［9］Deniau JM, Degos B, Bosch C, et al. Deep brain stimulation mechanisms: beyond the concept of local functional inhibition［J］. Eur J Neurosci, 2010, 32(7): 1080-1091. 
［10］Feng Zhouyan, Zheng Xiaojing, Yu Ying, et al. Functional disconnection of axonal fibers generated by high frequency stimulation in the hippocampal CA1 region invivo［J］. Brain Res, 2013, 1509: 32-42.
［11］封洲燕, 肖乾江, 胡振华. 电刺激期间神经细胞单元锋电位的检测［J］. 中国生物医学工程学报, 2013, 32(4):403-410.
［12］封洲燕, 邢昊昱, 田聪, 等. 大鼠海马 CA1 区前馈抑制和反馈抑制的作用特性［J］. 航天医学与医学工程, 2011, 24(3): 167-172.
［13］McCarren M, Alger BE. Usedependent depression of IPSPs in rat hippocampal pyramidal cells in vitro［J］. J Neurophysiol, 1985, 53(2): 557-571.
［14］Pearce RA, Grunder SD, Faucher LD. Different mechanisms for usedependent depression of two GABAAmediated IPSCs in rat hippocampus［J］. J Physiol, 1995, 484(Pt 2): 425-435.
［15］Théorêt Y, Brown A, Fleming SP, et al. Hippocampal field potential: a microcomputer aided comparison of amplitude and integral［J］. Brain Res Bull, 1984, 12(5): 589-595.［16］Freund T, Buzsaki G. Interneurons of the hippocampus［J］. Hippocampus, 1996, 6(4): 347-470.
［17］Margineanu DG, Wulfert E. Differential pairedpulse effects of gabazine and bicuculline in rat hippocampal CA3 area［J］. Brain Res Bull, 2000, 51(1): 69-74. 
［18］Leung LS, Peloquin P, Canning KJ. Pairedpulse depression of excitatory postsynaptic current sinks in hippocampal CA1 in vivo ［J］. Hippocampus, 2008, 18(10): 1008-1020.
［19］Davies CH, Davies SN, Collingridge GL. Pairedpulse depression of monosynaptic GABAmediated inhibitory postsynaptic responses in rat hippocampus［J］. J Physiol, 1990, 424: 513-531. 
［20］Jensen AL, Durand DM. High frequency stimulation can block axonal conduction［J］. Exp Neurol, 2009, 220(1): 57-70.
［21］Zheng Fang, Lammert K, NixdorfBergweiler BE, et al. Axonal failure during high frequency stimulation of rat subthalamic nucleus［J］. J Physiol, 2011, 589(Pt 11): 2781-2793.
［22］Kim E, Owen B, Holmes WR, et al. Decreased afferent excitability contributes to synaptic depression during highfrequency stimulation in hippocampal area CA1［J］. J Neurophysiol, 2012, 108(7): 1965-1976.
［23］Ratas I, Pyragas K. Effect of highfrequency stimulation on nerve pulse propagation in the FitzHugh-Nagumo model［J］. Nonlinear Dyn, 2012, 67(4): 2899-2908.
［24］Sceniak MP, MacIver MB. Cellular actions of urethane on rat visual cortical neurons in vitro［J］. J Neurophysiol, 2006, 95(6): 3865-3874.