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Response of Neuronal Population to High Frequency Electrical Stimulation in Rat Hippocampus |
College of Biomedical Engineering and Instrumentation Science, Key Laboratory of Biomedical Engineering of National Education Ministry, Zhejiang University, Hangzhou 310027, China |
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Abstract Deep brain stimulations (DBS) have been developed for treating brain diseases such as Parkinson’s disease and epilepsy. But the mechanisms underlying DBS are not clear yet. In order to study the effects of DBS on the neural networks of brain, both orthodromic and antidromichigh frequency stimulation (HFS) were respectively applied on afferent fibers and efferent fibers of the hippocampal CA1 region in anaesthetized rats. Synchronized firings of neuronal action potential (i.e., population spike, PS) of CA1 pyramidal cells were examined. Results showed that 50 Hz orthodromicHFS induced persistent PS firings, while 100 and 200 Hz orthodromicHFS induced much less PS firings. During antidromicHFS with different frequencies, every stimulation pulse evoked a PS. However, the PS amplitude decreased gradually. The decrease of PS amplitude was more rapid with higher stimulation frequency. Taken together, the HFS of axons has excitatory effects on the neuronal populations both upstream and downstream. But the higher the stimulation frequency is, the less the excitatory effect is. These results are important for the further understanding of DBS mechanisms and for the safe and effective application of DBS in clinic.
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