水凝胶材料和间充质干细胞在组织工程中的应用进展

doi:10.3969/j.issn.0258-8021.2020.03.15

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Abstract With the development of tissue engineering, there is an increasing focus on using hydrogel as scaffolds and 3D culture modes for tissue and organ regeneration. Hydrogel is formed by hydrophilic polymer, copolymer or a monomer macromolecule capable of forming a macromolecular chain, which can absorb a large amount of water and maintain a three-dimensional structure. Because of its good biocompatibility, entrapment of cells and bioactive molecules and effective delivery, they are widely used in drug delivery, tissue engineering and so on in the field of biomedicine. Mesenchymal stem cells can be obtained in bone marrow, fat, umbilical cord and other tissues with low immunogenicity and multidirectional differentiation potential, which are the preferred cells for 3D cultures and cell therapies. At present, the culture mode of mesenchymal stem cells is mainly 2D. The 2D culture mode of mesenchymal stem cells leads to low reproduction rate and cannot simulate the growth environment in vivo. Hydrogel materials as scaffolds of 3D culture have good compatibility, can simulate the growth environment in vivo, and have great potential in repairing damaged cartilage, such as bone, skin and heart tissues. In this review, we summarized the applications of hydrogels and mesenchymal stem cells in tissue engineering. We showed the development of hydrogel materials and 3D culture mode of mesenchymal stem cells in different tissues, showing that the 3D culture mode of hydrogel materials and mesenchymal stem cells makes it possible to regenerate and repair tissues and organs, and providing a reference for the further study of the application of hydrogel and stem cell.

Key words： hydrogel mesenchymal stem cells tissue engineering

Received: 23 September 2019

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R318

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	Articles by authors
	Li Min
	Meng Xiangjing
	Zhang Xiangkui
	Liu Bo
	Duan Chonggang
	Zhang Lanying
	Zhang Daizhou
	Ling Peixue

Cite this article:

Li Min,Meng Xiangjing,Zhang Xiangkui, et al. Progress in Application of Hydrogels and Mesenchymal Stem Cells in Tissue Engineering[J]. Chinese Journal of Biomedical Engineering, 2020, 39(3): 367-374.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2020.03.15 OR http://cjbme.csbme.org/EN/Y2020/V39/I3/367

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