基于脑电的意识障碍重复经颅磁刺激调控评估

doi:10.3969/j.issn.0258-8021.2019.06.006

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Abstract Recently, repetitive transcranial magnetic stimulation (rTMS) has been demonstrated to improve consciousness in patients with disorders of consciousness. However, there is significant difference of brain responses to rTMS between patients in minimally conscious state (MCS) and vegetative state (VS). This study aims to investigate the different effects of rTMS on the patients with disorders of consciousness, by measuring the EEG activity and functional connectivity. Twenty-four patients with disorders of consciousness were enrolled in real and sham rTMS sessions. The EEG (62 channels) was recorded before and immediately after rTMS. Relative power, phase-locking value and functional network properties were evaluated to assess brain changes induced by rTMS. After rTMS modulation, a significant increase power of Gamma band and enhanced functional connectivity were found in patients in MCS. And the enhanced connectivity was mainly located within fronto-central and fronto-parietal regions. In addition, network features derived from the graph theoretical analysis showed decrease of average path length (1.32±0.31 vs 1.08±0.22), increase of clustering coefficient (0.95±0.15 vs 1.12±0.21) and small-world characteristic (0.76±0.24 vs 1.06±0.32) in patients in MCS. No significant alterations were observed in gamma band for patients in VS. Given the role of high gamma activity in human consciousness and cognition. These results provided potential methods and mechanisms of evaluation rTMS effects in conscious rehabilitation of patients with disorders of consciousness.

Key words： repetitive transcranial magnetic stimulation EEG brain network minimally conscious state vegetative state

Received: 23 October 2018

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R318

Corresponding Authors: E-mail: xiaoli@bnu.edu.cn

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	Articles by authors
	Bai Yang
	Xia Xiaoyu
	Wang Yong
	He Jianghong
	Li Xiaoli

Cite this article:

Bai Yang,Xia Xiaoyu,Wang Yong, et al. Assessment Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Disorders of Consciousness by EEG[J]. Chinese Journal of Biomedical Engineering, 2019, 38(6): 687-694.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2019.06.006 OR http://cjbme.csbme.org/EN/Y2019/V38/I6/687

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