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| Study on Temperature Field of Biological Tissues During Low-Frequency Ultrasound TransdermalDrug Delivery |
| Zhao Ke1, He Bingbing1, Zhang Yufeng1,2#* |
1(Department of Electronic Engineering, Information School, Yunnan University, Kunming 650091, China)
2(Dianchi College of Yunnan University, Kunming 650228, China) |
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Abstract In the process of low-frequency ultrasound transdermal drug delivery, effects of the ultrasound frequency parameters on the temperature of biological tissues are still unclear. In this paper, finite element analysis (finite element analysis and in vitro experiments of biological tissues) was used to study the effects of low-frequency ultrasound of different frequencies on the temperature distribution of biological tissues, aiming to achieve the therapeutic effect without causing thermal damage to the skin layer of biological tissues. In order to verify the effectiveness of the model, a self-developed low-frequency ultrasonic energy output device was used to perform anex vivo pork test, and the temperature field distribution and temporal temperature changes of the isolated tissues under low-frequency ultrasound were monitored by a FLIR infrared thermal imager. The results of finite element analysis showed that after 20 minutes of low-frequency ultrasound, the temperature inside the biological tissue decreased with the increase of ultrasound frequency, and the temperature of the fat layer was the highest, reaching 40.89℃, and the temperature change of the skin layer displayed by the domain probe met the safety requirements of transdermal drug administration of low-frequency ultrasound. Different ultrasound frequency parameters have a significant effect on the temperature change of biological tissues under the action of low-frequency ultrasound. The in vitro experiments under the same ultrasonic parameter settings showed that the temperature field distribution and its maximum temperature value in the biological tissue were basically consistent with the values detected by the domain point probe of the simulation experiment, and the temperature difference was within 1℃, which is within a reasonable error range. From the simulation results and in vitro experimental results, it could be seen that the above ultrasound parameter settings did not cause thermal damage to skin tissue and achieved the purpose of effective treatment. The model established in this study is expected to predict the temperature change in tissues and provide a reference for the action time and parameter setting of low-frequency ultrasound transdermal drug delivery.
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Received: 24 July 2024
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Corresponding Authors:
*E-mail: zhangyf@ynu.edu.cn
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| About author:: #Member,Chinese Society of Biomedical Engineering |
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