纳米医学传感器在肿瘤标志物检测方面的应用

doi:10.3969/j.issn.0258-8021.2026.01.010

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Abstract The high mortality rate of cancer underscores the critical importance of early diagnosis, with biomarker detection serving as a pivotal approach that plays a vital role in routine physical examinations, preventive screening, recurrence monitoring, and other aspects of tumor-related healthcare. This article focuses on the applications of nanomedical sensors in tumor biomarker detection. Following a brief introduction to tumor biomarkers, medical sensors, and nanomaterials, we provided detailed discussions on biosensors based on various nanomaterials, including metallic nanoparticles, graphene, and magnetic nanoparticles, which utilize electrochemical or fluorescent signaling mechanisms. These sensors are applied to detect glycoprotein antigens, carcinoembryonic antigens, enzyme-based biomarkers, circulating tumor cells, nucleic acidsand other molecular markers. We highlighted their potential in early tumor diagnosis, disease progression monitoring, and prognostic follow-up, aiming to provide actionable insights for identifying patients′ latent malignancies and assisting clinicians in diagnosis. Looking ahead, nanomedical sensors are expected to integrate with artificial intelligence technologies to enhance detection performance, reduce costs, simplify operational workflows, and prioritize biocompatibility and safety of materials, thereby advancing the development of early-stage cancer diagnosis and treatment.

Key words： tumor markers nanomaterials nanotechnology medical sensors clinical testing and analysis

Received: 05 June 2025

PACS:

R318

Corresponding Authors: ^*E-mail: changchunrui@ncst.edu.cn

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	Articles by authors
	Qin Wei
	Li Jiahui
	Chang Chunrui
	Zhao Lijun

Cite this article:

Qin Wei,Li Jiahui,Chang Chunrui, et al. Application of Nanomedical Sensors in Tumor Marker Detection[J]. Chinese Journal of Biomedical Engineering, 2026, 45(1): 100-113.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2026.01.010 OR http://cjbme.csbme.org/EN/Y2026/V45/I1/100

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