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Chinese Journal of Biomedical Engineering  2023, Vol. 42 Issue (4): 420-430    DOI: 10.3969/j.issn.0258-8021.2023.04.005
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The Test-Retest Assessment of Apparent Fiber Density Measurements Using Diffusion Weighted Imaging in English
Luo Yichao1,2, Yan Jingguo1,2, Chen Yuanyuan2,3, Fan Qiuyun1,2,3*
1(School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China)
2(Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin 300072, China)
3(Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China)
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Abstract  Diffusion weighted imaging has been widely used in quantitative study of human brain white matter. Apparent fiber density (AFD) is a quantitative metric based on the fiber orientation distribution (FOD), which can reflect the fiber density of white matter and has been applied in the research of healthy development and neurodegenerative diseases. However, the value of AFD measurement strongly depends on experimental set-up, and the test-retest repeatability of AFD under different experimental conditions has not been systematically assessed. In this paper, the test-retest repeatability of AFD was examined at different diffusion weighted values (b-values) using the scan-rescan data of 42 subjects from two separate datasets. One dataset (n=35) is from Human Connectome Project (HCP), the other (n=7) is form Connectome Diffusion Microstructure Dataset (CDMD). The AFD value of fixel level was estimated using fixel-based analysis (FBA), and tract ROIs were obtained using TractSeg to estimate the fiber bundle averaged AFD. Results showed that at the fixel level, as the b-value increased, the Pearson’s correlation coefficient (r) and intraclass correlation coefficient (ICC) increased from 0.796 9 and 0.898 5 to 0.882 8 and 0.941 4 respectively in the test-retest experiment with HCP, and the absolute deviation decreased from 0.124 1 to 0.107 3. Similar trend was also found in the dataset from CDMD. At the tract-average level, the test-retest repeatability can be achieved at all b-values in both datasets. In summary, this paper examined the repeatability of AFD estimation for b-values in the range of 1 000~5 000 s·mm-2, and our results might provide useful insights into the experimental design in future neurobiological investigations using AFD.
Key wordsapparent fiber density      diffusion weighted imaging      intraclass correlation coefficient      test-retest repeatability     
Received: 10 March 2023     
PACS:  R318  
Corresponding Authors: *E-mail: fanqiuyun@tju.edu.cn   
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Luo Yichao
Yan Jingguo
Chen Yuanyuan
Fan Qiuyun
Cite this article:   
Luo Yichao,Yan Jingguo,Chen Yuanyuan, et al. The Test-Retest Assessment of Apparent Fiber Density Measurements Using Diffusion Weighted Imaging in English[J]. Chinese Journal of Biomedical Engineering, 2023, 42(4): 420-430.
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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2023.04.005     OR     http://cjbme.csbme.org/EN/Y2023/V42/I4/420
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