骨组织工程中调节巨噬细胞行为促进骨愈合的策略

doi:10.3969/j.issn.0258-8021.2022.05.010

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Abstract In bone tissue engineering, the biomaterial is implanted into the bone defect as a regeneration scaffold to help promote bone healing. With the development of osteoimmunology in recent years, people have realized that the immune response of macrophages determines whether the implantation is successful. Macrophages, which are diverse and plastic, can be polarized into M1-like (pro-inflammatory) and M2-like (anti-inflammatory) phenotypes according to environmental signals and play an important role in different stages of bone healing. Their behavior like migration, proliferation and polarization is sensitive to the properties of the material. This article reviews the current strategies of modulating the behavior of macrophages to promote bone healing by designing the physical properties, surface chemical properties, and biological properties of materials, including increasing the roughness of the material, macropores combining with nanostructures, appropriate electrical or mechanical signals, neutral or anionic surfaces, increasing hydrophilicity, using immunomodulatory materials or delivering immunological active substances to the defect area, etc., which provide ideas for the design of bone tissue engineering materials with good immunomodulatory properties.

Key words： bone tissue engineering macrophages polarization bone healing immunomodulation

Received: 01 September 2021

PACS:

R318

Corresponding Authors: * E-mail: qinshan@zju.edu.cn

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2022.05.010 OR http://cjbme.csbme.org/EN/Y2022/V41/I5/614

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