Study on the Parkinson's Disease EEG Tracing and Characteristics of Brain Functional Network
Wang Zhaoya1,2,3, Yao Yao4, Yin Ning1,2,3, Feng Keke4, Xu Guizhi1,2,3#*, Yin Shaoya4*
1(State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China) 2 (Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China) 3(Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China) 4(Department of Neurosurgery,Tianjin Huanhu Hospital,Tianjin 300350,China)
Abstract Parkinson's disease is a common neurodegenerative disease in the elderly, but there is still no recognized specific biochemical diagnostic index. To explore the EEG differences between Parkinson's disease patients and healthy subjects, the resting state EEG of 26 Parkinson's disease patients and 26 healthy subjects were collected. Subjects' cognitive function was assessed subjectively by MMSE and MoCA scales, and their motor function was assessed by UPDRS and H&Y scales. Firstly, the EEG of the two groups were traced by sLORETA, and then by adopting the method of lag phase synchronization of brain function network difference analysis, topological property of brain functional network of the two groups were compared and analyzed. The results showed that the occipital lobe and parietal lobe were the main brain regions of PD group compared with healthy control group, and the α2 band precuneus (BA7) current density was significantly decreased. The functional connectivity between the frontal lobe and occipital lobe in β1 band was significantly decreased, the mean clustering coefficient (C), global efficiency (Eg) and node degree (D) of patients' brain functional network weresignificantly lower than those of healthy control group (patients: C=0.54±0.14, Eg=0.71±0.09, D=26.88±9.88; healthy subjects:C=0.75±0.13, Eg=0.83±0.09, D=42.21±11.19), and the mean characteristic path length (L) of patients' brain functional network wassignificantly higher than that of healthy control group (patient: L =1.61±0.2; healthy subjects: L=1.34±0.19), with statistical significance (P<0.01). In this study, the α2 band precuneus (BA7) current density was significantly decreased and the decrease of functional the decrease of functional connection efficiency in β1 band have guiding significance for the diagnosis of PD.
Wang Zhaoya,Yao Yao,Yin Ning, et al. Study on the Parkinson's Disease EEG Tracing and Characteristics of Brain Functional Network[J]. Chinese Journal of Biomedical Engineering, 2022, 41(3): 257-265.
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