|
|
Study on the Brain Function Network of Transcranial Direct Current Stimulation Intervention on Working Memory |
Lu Sheng1, Luo Zhizeng1*, Shi Hongfei2, Gao Yunyuan1 |
1(Institute of Intelligent Control and Robotics,School of Automation,Hangzhou Dianzi University, Hangzhou 310018, China) 2(The Fourth Affiliated Hospital of Medical College of Zhejiang University, Jinhua 322000, Zhejiang,China) |
|
|
Abstract Working memory is an important basis of advanced cognitive function. In order to explore the effect of transcranial direct current stimulation on working memory and its specific mechanism, 18 subjects were recruited to participate in the experiment. The behavioral data (accuracy, reaction time) and EEG signals of subjects in the memory load task of three-picture, four-picture and five-picture after stimulation of sham/anode/cathode tDCS were collected. Firstly, the working memory ability was evaluated based on behavioral data. Then, the correlation of EEG signals between different channels was used to construct the brain functional network in each state, and the network characteristic parameters such as average degree(D), average clustering coefficient(C) and global efficiency(E) are calculated. Finally, the changes of behavior data and network characteristic parameters in three kind of memory load tasks after different tDCS stimulation are analyzed. It was shown that compared with sham tDCS(four-picture: 81.25%±2.30%;five- picture: 73.25%±5.36%), the accuracy of the four-picture and five-picture load tasks after anode tDCS (four-picture: 89.75%±1.36%;five- picture: 78.50%±2.25%) were significantly improved (P<0.05), but the behavior data after cathodic tDCS was irregular. According to the change of the characteristic parameters of brain functional network, the height value nodes after anode stimulation were mainly distributed in the stimulation point F3 and the surrounding area. The average degree, average clustering coefficient and global efficiency of the three kinds of memory load tasks were significantly increased compared with those after sham stimulation (P<0.05). The increase of the above three parameters in the four-picture task was the largest (sham tDCS:D=10.55±2.31,C=0.60±0.07,E=0.26±0.03; anodal tDCS: D=15.37±1.35,C=0.71±0.04,E=0.34±0.02). The height value nodes after cathode stimulation were mainly distributed in the right frontal lobe and occipital lobe. Only in the five-picture load task(sham tDCS:D=13.73±2.42, C=0.64±0.07,E=0.31±0.04;cathode tDCS:D=11.46±2.31,C=0.58±0.05,E=0.28±0.03), the average degree, average clustering coefficient and global efficiency are significantly reduced(P<0.05). The results showed that anode tDCS could effectively improve working memory performance by activating the activity of left dorsolateral prefrontal cortex, and the enhancement effect was more significant in the moderate difficulty task; cathode tDCS inhibited the activity of the cortex and reduce the connectivity of the brain, but the brain chose other brain regions for functional compensation, which showed great individual differences, and the inhibition effect was more significant in high difficulty tasks.
|
Received: 26 May 2020
|
|
|
|
|
[1] Brunoni AR, Nitsche MA, Bolognini N, et al. Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions[J].Brain Stimulation,2012, 5(3):175-195. [2] Purpura DP,Mcmurtry J g.Intracellular activities and evoked potential changes during polarization of motor cortex[J]. Journal of Neurophysiology, 1965, 28(1):166-185. [3] Nitsche MA,Fricke K, Henschke U,et al. Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans[J].Journal of Physiology (Cambridge), 2003, 553(1):293-301. [4] Wu Weifeng, Bowden MG, Kautz S. Review of transcranial direct current stimulation in poststroke recovery[J]. Topics in Stroke Rehabilitation, 2013, 20(1):68-77. [5] Monte-Silva K, Kuo MF, Hessenthaler S, et al. Induction of late ltp-like plasticity in the human motor cortex by repeated non-invasive brain stimulation[J].Brain Stimulation, 2012, 6(3):424-432. [6] Baddeley A. The episodic buffer: A new component of working memory?[J].Trends in Cognitive Sciences, 2000, 4(11):417-423. [7] Gartner M,Rohde-Liebenau L,Grimm S, et al. Working memory-related frontal theta activity is decreased under acute stress[J]. Psychoneu Roendocrinology,2014, 43:105-113. [8] Fregni F, Boggio PS, Nitsche, M. et al. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory[J]. Experimental Brain Research, 2005, 166(1):23-30. [9] Mylius V, Jung M, Menzler K, et al. Effects of transcranial direct current stimulation on pain perception and working memory[J]. European Journal of Pain, 2012, 16(7):974-982. [10] Oliveira JF, Zanão TA, Valiengo L, et al. Acute working memory improvement after tDCS in antidepressant-free patients with major depressive disorder[J]. Neuroence Letters, 2013, 537(6):60-64. [11] Teo F, Hoy K, Daskalakis Z, et al. Investigating the role of current strength in tDCS modulation of working memory performance in healthy controls [J]. Frontiers in Psychiatry / Frontiers Research Foundation, 2011, 2:45. [12] Keeser D, Padberg F, Reisinger E, et al. Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study[J]. Neuroimage, 2011, 55(2):644-657. [13] Sotnikova A, Soff C, Tagliazucchi E, et al. Transcranial direct current stimulation modulates neuronal networks in attention deficit hyperactivity disorder[J]. Brain Topography, 2017,30:656-672. [14] 尹宁,代扬杨,生晖,等.基于复杂网络的磁刺激内关穴脑皮层功能连接分析[J].中国生物医学工程学报,2019,38(6):695-701. [15] Hoy KE, Emonson MRL, Arnold SL, et al. Testing the limits: Investigating the effect of tDCS dose on working memory enhancement in healthy controls[J]. Neuropsychologia, 2013, 51(9):1777-1784. [16] Wang Niannian, Zhang Li, Liu Guozhong. EEG-based research on brain functional networks in cognition[J]. Bio Medical Materials & Engineering, 2015,26(1):1107-1114. [17] 杨骏,闫拓,薛青,等.老年人轻度认知障碍部分定向相干脑网络分析[J].中国生物医学工程学报,2013,32(4):390-396. [18] 杨桂芬,张云亭,张权,等.正常人参数性数字n-back工作记忆任务的去激活网络:fMRI研究[J].中国临床心理学杂志,2007(5):476-479. [19] 周鹏,魏晋文,孙畅,等.经颅直流电刺激调控大脑认知功能的研究进展[J].中国生物医学工程学报,2018,37(2):208-214. [20] Dedoncker J, Brunoni AR, Baeken C, et al. A systematic review and meta-analysis of the effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex in healthy and neuropsychiatric samples: Influence of stimulation parameters[J]. Brain Stimulation, 2016, 9(4):501-517. [21] Brunoni AR, Vanderhasselt MA. Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis[J]. Brain and Cognitsion,2014,86:1-9. |
[1] |
Xu Yun, Xu Kun, Chen Junyu, Xu Shuo. The Research Progress in Electrode Topology of Transcranial Direct Current Stimulation[J]. Chinese Journal of Biomedical Engineering, 2020, 39(3): 342-350. |
[2] |
Li Jipeng, Li Ying, Zhang Dongying, Feng Hao, Yin Ning. Research on the Influence of Music Type on Learning and Memory Based on EEG Signal Source Tracing Analysis[J]. Chinese Journal of Biomedical Engineering, 2019, 38(6): 679-686. |
|
|
|
|