Review on State-of-the-Art of Contrast-Enhanced Ultrasound Imaging
1 Beijing Shen Mindray Medical Electronics Technology Research Institute Co. Ltd., Beijing 100085, China
2 The General Hospital of Chinese People′s Liberation, Beijing 100853, China
3 Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China
Abstract Due to its characteristics of noninvasive, real-time, and high diagnosis ratios, contrast-enhanced ultrasound imaging has played an increasingly important role in cancer diagnosis. Herein, the latest research progress of contrast-enhanced ultrasound imaging was summarized in this paper, mainly including following aspects: 1) Subharmonic ultrasound imaging with a higher contrast-to-tissue ratio and superior penetration performance, which are due to detection of the lower frequency component of the microbubbles′ backscatter echoes; 2) Application of plane-wave emission technology in ultrasound contrast imaging that is capable of increasing temporal resolution whilst reducing microbubble′s destruction; 3) Coded excitation based ultrasound contrast imaging to obtain a better penetration; 4) Experimental research on new types of ultrasound contrast agents for ultrahigh frequency imaging.
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