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Analysis of Heating Mechanisms and Calculation of Temperature Rising Rate for Human Tissues in Radiofrequency Capacitive Hyperthermia |
School of Physics and Electronics, Hunan University, Changsha 410082, China |
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Abstract The purpose of this study is to clear up some misunderstandings in the heating mechanisms and in the temperature rising rate of different human tissues in radiofrequency (RF) capacitive hyperthermia. In this paper, the mechanisms of heating human tissues by RF capacitive hyperthermia are studied
on the basis of electromagnetic field theory. According to the model of neglecting fringing effect of plate electrodes in which filled with different dielectric layers, the expressions of the ratios of power loss per unit volume, specific absorption rate (SAR), and temperature rising rate for any two dielectrics were derived. Substituting the known electrical parameters and physical parameters of human muscle, fat and cortical bone into those expressions, we found that the temperature rising rate of fat and bone was 18.9 and 20.2 times as many as that of muscle at 27.12 MHz, while 19.8 and 19.1 times at 40.68 MHz. We concluded that in RF capacitive hyperthermia process, the larger the conductivity of human tissue, the smaller the temperature rising rate. And the temperature rising rate for different tissue is very inhomogeneous in RF capacitive hyperthermia.
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[1]唐劲天,郭静,阳兵,等.热疗的发展历程与展望 [J]. 科技导报, 2014, 32(30):15-18.
[2]Konstantin PT, Liubov AO, Sergey VZ, et al. Radio frequency radiationinduced hyperthermia using Si nanoparticlebased sensitizers for mild cancer therapy. Scientific Reports, 2014, 4:7034.
[3]李鼎九,孔忆寒. 肿瘤热疗的理论与临床 [M]. 郑州:郑州大学出版社, 2010: 182-195.
[4]赵镇南,丰彤,王海磐. 双频双对电极射频热疗比吸收率及温度场模拟 [J]. 中国生物医学工程学报, 2006, 23(1): 16-20.
[5]程晓曼,万柏坤,罗经国,等. 电容射频热疗中引入内电极对深部热场分布影响的仿真研究 [J]. 中国生物医学工程学报, 1998, 17(6): 135-141.
[6]丰惠芬,王雪顽,张连成. 射频加热技术及其在医学上的应用 [J]. 高电压技术, 1994, 20(4): 30-33.
[7]唐茹冰,王存诚. 射频加热治疗肿瘤体模实验的数值模拟 [J]. 清华大学学报( 自然科学版), 2002, 42(5): 676-679.
[8]万柏坤,毕卡诗,程晓曼,等. 电容射频热疗中深部有效热区优化方法研究 [J]. 中国生物医学工程学报, 2003, 22(5): 385-392.
[9]贺晓东,翁霞,叶影,等. 射频体外加温体模内热场分布研究 [J]. 中国生物医学工程学报, 2005, 245): 560-565.
[10]王祝盈,董卉慎,刘珈,等. 肿瘤热疗技术中平面电磁波与人体相作用的研究 [J]. 北京生物医学工程, 2006, 25(3): 288-292.
[11]林世寅,李瑞英. 现代肿瘤热疗学 [M]. 北京:学苑出版社, 1997: 120-137.
[12]李鼎九,胡自省. 肿瘤热疗学 [M]. 郑州:河南医科大学出版社, 1995: 139-148.
[13]Gabriel C. Compilation of the dielectric properties of body tissues at RF and microwave frequencies [R], Report N.AL/OETR- 1996-0037, Occupational and environmental health directorate, Radiofrequency Radiation Division, Brooks Air Force Base, Texas (USA), June 1996.
[14]万柏坤,程晓曼,罗经国,等. 两极板电容式射频热疗中比吸收率分布的模拟计算和体模实验研究 [J]. 中国生物医学工程学报, 1996, 15(2) : 122-127.
[15]张淑慧,刘邦,杨敬贤,等. 热疗联合放疗和化疗治疗恶性肿瘤不良反应的观察与预防 [J]. 中国医学物理学杂志, 2012, 29(6) : 3748-3751.
[16]秦苑,任东,范宇飞,等. 腹腔内灌注重组人p53腺病毒注射液及顺铂结合局部亚高温热疗治疗恶性腹水观察 [J]. 实用临床医药杂志, 2011, 15(13):15-17.
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