2相早期后除极对心肌电折返稳定性的影响

doi:doi:103969/j.issn.0258-8021.2015.01.004

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Abstract The voltage oscillations at the phase 2 repolarization of an action potential are called the phase2 early afterdepolarizations (EADs). Most isolated myocyte studies have recorded phase2 EADs, but their characteristics in the tissue and whether they affect the electrical stability and behaviors of the ventricular tachycardia (VT) and ventricular fibrillation (VF) are still not clear. In this paper, based on the single cell LuoRudy ionic mathematical model, the phase2 EADs were produced by properly matching the maximum conductance of Ca²⁺ ionic channel and the time constant of K+ gating. A two dimensional inhomogeneous tissue model including 400×400 cells was then developed by putting the local EAD regions inside. The operator splitting technique was used to integrate the tissue model. The cross field method was utilized to induce a reentry and formed a spiral wave. The effects of EAD on the dynamics of spiral wave patterns were observed. Results showed that phase-2 EAD could promote the destabilization of the spiral wave and its breakup, but whether this transition occurred was dependent on the size and location of the EADs. A 20×20 EAD zone in the center was easy to result in breakup of the spiral wave. Multiple EAD regions could aggravate the destabilization, leading to the more chaotic wave patterns. The refractory period dispersion was suggested to be the main mechanism of the wave breakup. Therefore, phase2 EAD could promote the degeneration of VT to VF. In the clinic setting, the inhibition of phase2 EADs was necessary for the prevention and suppression of the occurrence of VF.

Key words： early afterdepolarization reentry spiral wave voltage pattern action potential model

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	Articles by authors
	Zhang Hong^1*Zhao Dan¹He Ruirui¹Huang Xin²Fan Yaping^3

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Zhang Hong^1*Zhao Dan¹He Ruirui¹Huang Xin²Fan Yaping^3. Effects of Phase 2 Early Afterdepolarization on the Stabilities of Electrical Reentry[J]. journal1, 2015, 34(1): 24-29.

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http://cjbme.csbme.org/EN/doi:103969/j.issn.0258-8021.2015.01.004 OR http://cjbme.csbme.org/EN/Y2015/V34/I1/24

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