光学脑成像检测静息态下双侧语言皮层活动的同步性

doi:10.3969/j.issn.0258-8021. 2014. 04.04

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Abstract To investigate the synchronization of human bilateral cortical spontaneous activities in language areas and the relationship between the synchronization and language ability, optical brain imaging was used to measure resting state cortical activities in language areas of subjects with different language ability. The measured signals included temporal fluctuations of oxygenated and deoxygenatedhemoglobin. Three groups of subjects participated in the experiment, including 25 children with autism, 11 normal children and 20 normal adults. Fortyfour optical channels were used in the experiment to record the spontaneous fluctuations for 8 minutes from bilateral inferior and temporal cortices. After the recorded signals were filtered and processed to remove the global systemic interference, the temporal correlation coefficient was calculated for each channel pair located symmetrically on the left and the right hemisphere. This correlation coefficient reflects the synchronization of activities arising from cortical regions right beneath the channel pair. The average interhemispheric correlation coefficients for the symmetric regions of interest (e.g., inferior frontal cortex, temporal cortex) were also calculated and quantitatively compared between the three groups of subjects. Our data show the average interhemispheric correlations for temporal language cortices are different between subject groups: the correlation for children with autism (r=0.306±0.039) is significantly (P=0.048) lower than that for normal children (r=0.472±0.037), normal children is significantly (P=0.00058) lower than normal adults (r=0.639±0.020), and adult males (r=0.604±0.035) is slightly lower than adult females (r=0.673±0.017), but not significantly (P >0.05). These results imply optical brain imaging may provide qualitative and quantitative evaluation on the functioning of human brain language network.

Key words： biological and medical applications optical imaging of neuronal activity neuroscience hemodynamics

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	LI Jun^*QIU Li Na ZHU Hui Lin ZHU Zhi Fang

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LI Jun^*QIU Li Na ZHU Hui Lin ZHU Zhi Fang. Synchronization of Resting State Bilateral Cortical Activities in Language Areas Measured with Optical Brain Imaging[J]. journal1, 2014, 33(4): 410-417.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014. 04.04 OR http://cjbme.csbme.org/EN/Y2014/V33/I4/410

［1］Villringer A, Chance B. Noninvasive optical spectroscopy and imaging of human brain function ［J］. Trends in Neurosciences, 1997, 20(10): 435-442. 
［2］Hoshi Y. Functional nearinfrared optical imaging: utility and limitations in human brain mapping ［J］. Psychophysiology, 2003, 40(4): 511-520.
［3］Funane T, Kiguchi M, Atsumori H, et al. Synchronous activity of two people’s prefrontal cortices during a cooperative task measured by simultaneous nearinfrared spectroscopy ［J］. Journal of Biomedical Optics, 2011, 16(7): 077011-077011-10.
［4］Quaresima V, Bisconti S, Ferrari M. A brief review on the use of functional nearinfrared spectroscopy (fNIRS) for language imaging studies in human newborns and adults ［J］. Brain and Language, 2012, 121(2): 79-89.
［5］Hillman EMC. Optical brain imaging in vivo: techniques and applications from animal to man ［J］. Journal of Biomedical Optics, 2007, 12(5): 051402-051402-28. 
［6］Li Jun, Dietsche G, Iftime D, et al. Noninvasive detection of functional brain activity with nearinfrared diffusingwave spectroscopy ［J］. Journal of Biomedical Optics, 2005, 10(4): 044002-044002-12.
［7］Gratton G, Fabiani M. Dynamic brain imaging: eventrelated optical signal (EROS) measures of the time course and localization of cognitiverelated activity ［J］. Psychonomic Bulletin & Review, 1998, 5(4): 535-563.
［8］Kahlaoui K, Vlasblom V, Lesage F, et al. Hemispheric specialization for the semantic processing of words during aging: a nearinfrared spectroscopy study ［J］. Brain and Cognition, 2008, 67: 25.
［9］LABNIRS,http://www.shimadzu.com/an/lifescience/imaging/nirs/nirs3.html, 2014-05-22.
［10］Gratton G, Brumback CR, Gordon BA, et al. Effects of measurement method, wavelength, and sourcedetector distance on the fast optical signal ［J］. Neuroimage, 2006, 32: 15761590.
［11］White BR, Culver JP. Quantitative evaluation of highdensity diffuse optical tomography: in vivo resolution and mapping performance ［J］. Journal of Biomedical Optics, 2010, 15(2): 026006.
［12］Biswal B, Zerrin Yetkin F, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echoplanar mri ［J］. Magnetic resonance in medicine, 1995, 34(4): 537-541.
［13］Greicius MD, Krasnow B, Reiss AL, et al. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis ［J］. Proceedings of the National Academy of Sciences, 2003, 100(1): 253-258.
［14］Xiang Huadong, Fonteijn HM, Norris DG, et al. Topographical functional connectivity pattern in the perisylvian language networks ［J］. Cerebral Cortex, 2010, 20(3): 549-560.
［15］White BR, Snyder AZ, Cohen AL, et al. Restingstate functional connectivity in the human brain revealed with diffuse optical tomography ［J］. Neuroimage, 2009, 47(1): 148-156.
［16］Lu Chunming, Zhang Yujin, Biswal BB, et al. Use of fNIRS to assess resting state functional connectivity ［J］. Journal of Neuroscience Mthods, 2010, 186(2): 242-249.
［17］Mesquita RC, Franceschini MA, Boas DA. Resting state functional connectivity of the whole head with nearinfrared spectroscopy ［J］. Biomedical Optics Express, 2010, 1(1): 324-336.
［18］Duan Lian, Zhang Yujin, Zhu Chaozhe. Quantitative comparison of restingstate functional connectivity derived from fNIRS and fMRI: a simultaneous recording study ［J］. Neuroimage, 2012, 60(4): 2008-2018.
［19］Zhang Yujin, Lu Chunming, Biswal BB, et al. Detecting restingstate functional connectivity in the language system using functional nearinfrared spectroscopy ［J］. Journal of Biomedical Optics, 2010, 15(4): 047003-047003-8.
［20］Li Jun, Qiu Lina. Temporal correlation of spontaneous hemodynamic activity in language areas measured with functional nearinfrared spectroscopy ［J］. Biomedical Optics Express, 2014,5(2): 587-595. 
［21］Hagmann P, Cammoun L, Martuzzi R, et al. Hand preference and sex shape the architecture of language networks ［J］. Human Brain Mapping, 2006, 27(10): 828-835. 
［22］Dronkers NF, Wilkins DP. Lesion analysis of the brain areas involved in language comprehension ［J］. Cognition, 2004, 92(1): 145-177. 
［23］Gernsbacher MA, Kaschak MP. Neuroimaging studies of language production and comprehension ［J］. Annual Review of Psychology, 2003, 54(1): 91-114.
［24］Martin RC. Language processing: functional organization and neuroanatomical basis ［J］. Annual Review of Psychology, 2003, 54(1): 55-89.
［25］Dinstein I, Pierce K, Eyler L, et al. Disrupted neural synchronization in toddlers with autism ［J］. Neuron, 2011, 70(6): 1218-1225. 
［26］Zhu Huilin, Fan Yuebo, Guo Huan, et al. Reduced interhemispheric functional connectivity of children with autism spectrum disorder: evidence from functional near infrared spectroscopy studies ［J］. Biomedical Optics Express, 2014, 5(4): 1262-1274.
［27］Hahne A, Eckstein K, Friederici AD. Brain signatures of syntactic and semantic processes during children’s language development ［J］. Journal of Cognitive Neuroscience, 2004, 16(7): 1302-18.
［28］Sommer IEC, Aleman A, Bouma A, et al. Do women really have more bilateral language representation than men? a metaanalysis of functional imaging studies ［J］. Brain, 2004, 127(8): 1845-1852.
［29］Wallentin M. Putative sex differences in verbal abilities and language cortex: a critical review ［J］. Brain and Language, 2009, 108(3): 175-183.
［30］Okamoto M, Dan H, Sakamoto K, et al. Threedimensional probabilistic anatomical craniocerebral correlation via the international 1020 system oriented for transcranial functional brain mapping ［J］. Neuroimage, 2004, 21(1): 99-111.
［31］Murphy K, Birn RM, Handwerker DA, et al. The impact of global signal regression on resting state correlations: are anticorrelated networks introduced? ［J］. Neuroimage, 2009, 44(3): 893-905.
［32］Brauer J, Anwander A, Friederici AD. Neuroanatomical prerequisites for language functions in the maturing brain ［J］. Cerebral Cortex, 2011, 21:459-466.
［33］Northam GB, Liégeois F, Tournier JD, et al. Interhemispheric temporal lobe connectivity predicts language impairment in adolescents born preterm ［J］. Brain, 2012,135: 3781-3798.
［34］Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? ［J］. Neuropsychology Review, 2005, 15: 59-71.
［35］Northam GB, Liégeois F, Tournier JD, et al. Interhemispheric temporal lobe connectivity predicts language impairment in adolescents born preterm ［J］. Brain, 2012, 135:3781-3798.
［36］Dick AS, Beharelle AJ, Solodkin A, et al. Interhemispheric functional connectivity following prenatal or perinatal brain injury predicts receptive language outcome ［J］. The Journal of Neuroscience, 2013, 33(13): 5612-5625.
［37］Fair DA, Cohen AL, Dosenbach NUF, et al. The maturing architecture of the brain’s default network ［J］. Proceedings of the National Academy of Sciences, 2008, 105(10): 4028-4032.