纤维基组织工程支架结构对细胞行为的影响

doi:10.3969/j.issn.0258-8021.2018.03.015

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Abstract Effective strategies to guide cell growth are critical for the development of engineered tissues,and the surface morphology and properties of the biomaterials have appreciable impact on the biocompatibility and biological function, thus the regulation of cell behaviors can provide theoretical supports for developing biocompatible tissue engineering scaffolds. The fibrous scaffolds fabricated by electrospinning could mimic the network structure of the natural extracellular matrix (ECM), supporting cell attachment and guiding tissue formation, therefore fabricating micro- or nanofibers scaffolds are becoming of great interest in the area of biomaterials and tissue engineering. The effect of structural parameters of electrospun scaffolds on the cell behavior was reviewed in this paper, including fiber diameter, pore size, and fiber arrangement. The perspective of fibrous scaffolds and the current improved electrospinning methods for preparing different fibrous structures were also summarized.

Key words： electrospinning fiber diameter alignment pore size cell behavior

Received: 10 October 2017

PACS:

R318

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	Articles by authors
	Li Qiwei
	Li Chaojing
	Wang Fujun
	Ding Wen
	Hu Sihan
	Wang Lu

Cite this article:

Li Qiwei,Li Chaojing,Wang Fujun, et al. Effects of Fibrous Scaffolds Structure on Cell Behavior[J]. Chinese Journal of Biomedical Engineering, 2018, 37(3): 372-379.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2018.03.015 OR http://cjbme.csbme.org/EN/Y2018/V37/I3/372

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