肝素连接苯丙氨酸血液净化材料去除内毒素的研究

doi:10.3969/j.issn.0258-8021.2013.03.013

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Abstract In this work heparin–conjugating phenylalanine was linked to chloromethyl resin to prepare a new, safe, nontoxic adsorbent for endotoxin clearance. The optimal experimental conditions were determined by changing the amounts of reactants, reaction time and pH value. The performance of the heparinconjugating phenylalanine adsorbent were studied under the conditions of being in water and blood plasma, different initial concentration of endotoxin and the different lasting time. Additionally blood compatibility of the absorbent was evaluated. In dialyzing imitation experiments in water and in rabbit plasma, the endotoxin concentration was reduced to a low level after 2 hours of absorbent exposure. The maximum clearance rate was up to 79% and 72% in water and in the plasma respectively. The influence of the absorbent upon the concentrations of other substances in the blood was below 10%, showing excellent blood compatibility

Key words： endotoxin heparin phenylalanine hemoperfusion material

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	JIN Xin Xin¹WANG Xiang^1*MAO Jin Chun¹TANG Fu Zhou¹XIONG Yan Lian^1

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JIN Xin Xin¹WANG Xiang^1*MAO Jin Chun¹TANG Fu Zhou¹XIONG Yan Lian^1. Research of HeparinConjugating Phenylalanine Blood Purification Material to Remove Endotoxin[J]. journal1, 2013, 32(3): 348-355.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2013.03.013 OR http://cjbme.csbme.org/EN/Y2013/V32/I3/348

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