Abstract：In the past decades, drug delivery systems based on nanoparticles have been increasingly applied in medical fields, aiming to improve the target activity of drugs and reduce the untoward effects. Among various polymers, albumin is an ideal material for the formulation of nanoparticle-based drug delivery systems. As the most abundant protein in plasma, albumin has many advantages, such as good biocompatibility, biodegradability and lack of immunogenicity. There is a list of approaches to prepare albumin nanoparticles, including desolvation, self-assembly, emulsification, double emulsification, thermal gelation, spray drying, nab-technology and pH-coacervation. Due to the differences in the mechanism and conditions of preparation, each method has its own advantages and disadvantages. This article provided an overview of research progresses in different albumin-based formulations according to preparation methods. The current difficulties confronted by albumin nanoparticles and the future development directions were also discussed.
李艳, 蓝锦晓, 罗成. 白蛋白纳米颗粒的制备研究进展[J]. 中国生物医学工程学报, 2019, 38(1): 112-119.
Li Yan, Lan Jinxiao, Luo Cheng. Recent Advances in Preparation of Albumin Nanoparticle Systems. Chinese Journal of Biomedical Engineering, 2019, 38(1): 112-119.
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