Research Progress of Protein Adsorption on Hydroxyapatite Surface
Fu Yakang1*, Zhang Kehong1, Weng Jie2, Liu Yaowen3
1Ya'an Polytechnic College, Ya'an 625000, Sichuan, China; 2Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 3School of Food, Sichuan Agricultural University, Ya’an 625014, Sichuan, China
Abstract：This paper summarized the research progress of protein adsorption on hydroxyapatite (HAP) in the past 30 years, including adsorption mechanism, crucial factors and related application exploration. The adsorption mechanisms include electrostatic attraction, hydrogen bond and van der Waals force. The crucial factors include exposing crystal faces of HAP, specific surface area, concentration of PO43- and Ca2+, pH and temperature in the adsorption environment. In addition, this article introduced the application research of protein adsorption on HAP in the field of drug sustained-release carrier and bone tissue engineering scaffold. This review aimed to provide comprehensive introduction of advances for exploring the biological activity and special adsorption function design of HAP.
付亚康, 张科宏, 翁杰, 刘耀文. 羟基磷灰石表面蛋白质吸附的研究进展[J]. 中国生物医学工程学报, 2018, 37(6): 756-764.
Fu Yakang, Zhang Kehong, Weng Jie, Liu Yaowen. Research Progress of Protein Adsorption on Hydroxyapatite Surface. Chinese Journal of Biomedical Engineering, 2018, 37(6): 756-764.
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