Abstract：Wound repair is one of the core research directions in the fields of traumatology and biomaterials. For complex refractory wounds such as chronic diabetic foot ulcers and deep burns, conventional dressings suffer from inherent limitations including limited moist environment maintenance capacity, suboptimal infection prevention and control efficacy, and prolonged healing cycles, failing to meet clinical treatment demands. With the interdisciplinary integration of materials science, biomedicine and clinical medicine, novel medical dressings can effectively improve wound repair quality by mimicking the physiological barrier function of skin and actively regulatingwound microenvironments. This review systematically summarized the research progress of novel medical dressings,including hydrogels, hydrocolloids, foams, alginates, silver-ion, and nanofibers dressings based on material properties. Thekey components, material characteristics, wound healing-promoting mechanisms, clinical application outcomes and existing challengeswere elaborated.At the same time, future development directions were prospected from three dimensions including multi-component synergistic design, precise targeted regulation and construction of clinical translation systems.
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