聚乳酸生物可吸收支架在静态和动态系统中降解行为的研究

doi:10.3969/j.issn.0258-8021. 2014. 04.09

摘要
图/表
参考文献
相关文章 (0)

全文: PDF (2542 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要本研究通过建立体外静态和动态降解系统，探讨聚乳酸 (PLLA）生物可吸收支架在体外动态和静态降解系统中的降解行为及之间的关系。研究采用凝胶渗透色谱（GPC）、调制式示差扫描量热仪（MDSC）等手段表征支架材料相对分子质量及热力学性能，采用扫描式电子显微镜(SEM)、电子天平、非接触式显微镜测量系统及径向力测试仪分别测量支架的表面形貌、质量、支架外径及支撑力。结果显示，在静态和动态降解系统中，PLLA支架表观随降解时间增加没有明显区别；材料相对分子质量在降解6个月后分别下降至61.7% 和68.5%，但下降趋势相似；在动态降解系统中支架材料相对分子质量的多分散性指数（PDI）要大于静态降解系统中的；支架材料在降解过程中各阶段的热力学性能无明显差异；支架的外径变化趋势相似；径向支撑力在两个降解系统中的变化量均不大。支架材料在静、动态降解系统中的降解行为较为相似，在血管重建期内的6个月内可用静态降解系统代替昂贵、复杂的动态降解系统来研究PLLA生物可吸收支架产品的降解行为

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：生物可吸收支架, 静态降解行为, 动态降解行为

Abstract：In this study, static and dynamic degradation systems were set up to understand the degradation behaviors of PLLA (polyllactic acid）bioresorbable scaffolds (BRS) between the two systems. GPC and MDSC methods were employed to characterize molecular weight and thermodynamic properties of the material. Surface morphology, mass loss, diameter and radial strength of BRS were evaluated by scanning electron microscope (SEM), electronic balance, noncontact measurement system and radial force tester, respectively. The results showed that molecular weight (Mw) of the BRS kept dropping in static and dynamic systems with increasing degradation time, and it was reduced to 61.7% and 68.5% of their original Mw_(0) respectively after six months, but there were no significant differences between the two systems. Polydispersity index（PDI）of PLLA in the dynamic system was larger than that in the static system, suggesting inhomogeneous degradation in the dynamic degradation system. Thermodynamic properties, the surface morphology and the changes of outside diameters（OD）as well as the radial strengths were quite similar in the two systems. Based on these results, the complex dynamic degradation system could be replaced by the static degradation system for studying degradation behaviors of PLLA BRS products within 6 months.

Key words： bioresorbable scaffolds static degradation dynamic degradation

基金资助:2013年上海市科技支撑计划项目（13441902700）；2011年上海市科技创新行动计划—研发基地与研发平台建设领域（11DZ2280100）；2011年上海市浦江人才计划（11PJ1432500）

引用本文:

罗七一^1,2黄楚波^2*王帅²孟娟^{2&nbs. 聚乳酸生物可吸收支架在静态和动态系统中降解行为的研究[J]. 中国生物医学工程学报, 2014, 33(4): 447-454.

LUO Qi Yi^1,2 HUANG Chu Bo^2*WANG Shuai²MENG Juan²CHANG Zhao Hua^1,2ZHU Yu Fang}

链接本文:

http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021. 2014. 04.09 或 http://cjbme.csbme.org/CN/Y2014/V33/I4/447

［1］Stack RS, Califf RM, Phillips HR, et al. Interventional cardiac catheterization at Duke Medical Center［J］. Am J Cardiol, 1988, 62(10 Pt 2):3F-24F.
［2］Onuma Y, Serruys PW. Bioresorbable scaffold: The advent of a new era in percutaneous coronary and peripheral revascularization?［J］. Circulation, 2011,
123(7):779-797.
［3］Diletti R, Serruys PW, Farooq V, et al. ABSORB II randomized controlled trial: A clinical evaluation to compare the safety, efficacy, and performance of the Absorb everolimuseluting bioresorbable vascular scaffold system against the XIENCE everolimuseluting coronary stent system in the treatment of subjects with ischemic heart disease caused by de novo native coronary artery lesions: Rationale and study design［J］. AM Heart J, 2012, 164(5):654-663. 
［4］杨宁，李为民，李悦, 等. 生物可吸收支架的前景与挑战［J］.心血管病学进展,2010,31(1):75-78. 
［5］Tsuji H, Ikada Y. Properties and morphology of poly(llactide) 4. Effects of structural parameters on longterm hydrolysis of poly(llactide) in phosphatebuffered solution ［J］. Polym Degrad Stab, 2000, 67(1):179-189.
［6］von Recum HA, Cleek RL, Eskin SG, et al. Degradation of polydispersed poly(llactic acid) to modulate lactic acid release ［J］.Biomaterials, 1995, 16 (6):441-447.
［7］Weir NA, Buchanan FJ, Orr JF, et al. Degradation of polyLlactide. Part 1: in vitro and in vivo physiological temperature degradation ［J］. P I Mech Eng H, 2004, 218 (5):307-319.
［8］Alexis F. Factors affecting the degradation and drugrelease mechanism of poly(lactic acid) and poly (lactic acid)co(glycolic acid)［J］. Polym Int, 2005, 54(1):36-46.
［9］Erbel R, Di Mario C, Bartunek J, et al. Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, nonrandomised multicentre trial ［J］. Lancet, 2007, 〖STHZ〗369〖STBZ〗(9576):18691875. 
［10］张瑞敏，冯海全，陈彦龙,等.基于有限元分析的冠脉支架疲劳强度研究［J］.机械设计与制造,2013,(2):268-271.
［11］ASTM F16352011, Standard Test Method for in vitros Degradation Testing of Hydrolytically Degradable Polymer Resins and Fabricated Forms for Surgical Implants［S］. ［12］张艺，程开良，许家瑞，等.调制式差示扫描量热法在高分子研究中的应用［J］.化学通报,2004,67(5):341-348.
［13］Verheye S, Ormiston JA, Stewart J, et al. A nextgeneration bioresorbable coronary scaffold system: from bench to first clinical evaluation［J］. J Am Coll Cardiol, 2014,7(1):89-99.
［14］Serruys PW, Onuma Y. Unresolved issues and outlook: Ongoing trials and future technology［R］. EuroPCR, 2013.
［15］樊瑜波，曾莉，李萍, 等. 应力对D,L聚乳酸泡沫衬垫降解的影响研究［J］.中国生物医学工程学报, 2007,26(5):767-774.