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中国生物医学工程学报
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微波消融有效消融体积模型实验研究
1 南京航空航天大学生物医学工程系, 南京 210016
2 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院, 长沙 410013
Experimental Study on Effective Microwave Ablation Volume Model
1 Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
2 The Affiliated Tumor Hospital of Xiangya Medical School of Central South University / Hunan Provincial Tumor Hospital, Changsha 410013, China
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摘要 针对微波消融治疗需要监测消融区域的温度变化状态和获取有效消融体积的问题,通过离体猪肝实验,分析了消融区域的温升规律并建立了微波消融有效消融体积的数学模型。共进行了112例离体猪肝实验,采用40~70 W的不同微波功率和300~600 s的不同作用时间进行微波消融。实验在70 W微波功率作用下,实时采集了距离微波消融针5、10、15、20 mm处的毁损区域温度,对采用不同微波功率和作用时间得到的有效消融区域的短径、长径及体积数据进行了分析,并利用1stopt软件进行拟合。结果显示,消融区域不同位置的升温速度不同,距离微波针5 mm位置的升温速度为20 mm处的10倍左右;得到了有效消融区域的短径、长径和体积有关微波功率和作用时间的离体组织数学模型。消融区域的温升状态监测和有效消融体积模型的建立,有助于优化微波消融的术前治疗计划和进行实时消融治疗的效果评估。
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赵金哲1 钱志余1*刘珈2 &nb
关键词 微波消融毁损区域体积模型手术计划    
Abstract:Temperature variation in ablated area and effective ablation volume are very important parameters for microwave ablation treatment. In order to provide reference for realtime assessment of ablation efficacy, in vitro porcine liver experiments were carried out to monitor tissue temperature and build effective microwave ablation volume models in this work. Microwave power of 40~70 W and ablation time of 300~600 s were chosen to perform total 112 microwave ablations. The microwave power of 70 W was used in the first group of experiments and temperature changes at sites 5, 10, 15 and 20 mm away from microwave antenna were recorded in realtime during ablation. In the second group of experiments, different combinations of power and time produced a series of data of short axis, long axis and volume. Results showed that the increase of temperature near the microwave antenna was more rapid. Temperature rise at 5 mm away from the antenna was 10 times faster than that at 20 mm away. Volume data of the ablation area was analyzed using 1stopt to build experimental models for the short axis, long axis and volume of the ablation zone. Consequently, the monitoring of temperature and utilization of effective volume models will contribute to the microwave ablation surgical planning and realtime ablation efficacy assessment.
Key wordsmicrowave ablation    ablation zone    volume model    surgical planning
    
基金资助:国家自然科学基金(61275199);江苏省普通高校研究生科研创新计划资助项目(CXLX13_147)
引用本文:   
赵金哲1     钱志余1*刘珈2  &nb. 微波消融有效消融体积模型实验研究[J]. 中国生物医学工程学报, 2014, 33(1): 51-56.
ZHAO Jin Zhe1      QIAN Zhi Yu1* LIU Jia2        WU Jia Li1      WANG . Experimental Study on Effective Microwave Ablation Volume Model. journal1, 2014, 33(1): 51-56.
链接本文:  
http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2014. 01.08     或     http://cjbme.csbme.org/CN/Y2014/V33/I1/51
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