A Comparative Study on Dielectric Properties of Human Thyroid Normal and Tumor Tissues from 10 Hz to 100 MHz
Shi Xuetao1#Δ, ZhouYimin1#Δ, Ji Zhenyu1, Cai Zhanxiu2, You Fusheng1, Fu Feng1, Dong Xiuzhen1#*
1School of Biomedical Engineering, Forth Military Medical University, Xi'an 710032, China; 2School of Bioscience and Technology, Weifang Medical University,Weifang 261053, Shandong, China
Abstract：The aim of this study was to investigate the dielectric properties of normal and tumor tissues of human thyroid, make clear the difference between the dielectric parameters of those tissues, and to provide a basis for the rapid identification of pathological thyroid tissues based on dielectric properties. The dielectric properties of 135 thyroid tissues were measured ex vivo at frequency range of 10 Hz to 100 MHz using the standardized measurement platform. Then the samples were classified according to the pathological results, and the differences in dielectric properties of each group were found after statistical analysis. The samples can be divided into three groups: normal (95 cases), malignant tumor (19 cases) and benign tumor (21 cases). All of these samples have shown an increase in conductivity with increasing frequency, and 2 main frequency dispersion regions of α and β were also observed at the frequency range of 10 Hz~100 MHz. Through the modeling analysis, the characteristic parameters of the dielectric properties, ρ∞(Ω·cm), ρ0(Ω·cm), fcα(kHz), δα, fcβ(MHz) and δβ, were investigated. Normal thyroid tissue was 54.8±27.5, 385.6±3.3, 40.3±10.9, 0.61±0.04, 97.7±1.7 and 0.48±0.05, respectively. Benign tumor tissue was 118.3±8.5, 418.1±84.5, 26.3±13.1, 0.62±0.04, 3.5±0.8 and 0.56±0.06, respectively. Malignant tumor tissue was 67.7±5.1, 592.9±73.3, 10.2±2.6, 0.66±0.06, 6.37±4.1 and 0.36±0.07, respectively. Statistical analysis results indicated that the dielectric properties of normal thyroid tissue significantly different from that of malignant tumor tissue in parameters of ρ0, fcα,fcβand δβ, which was also significantly different from that of benign tumor tissue in parameters of ρ∞, fcα and δβ. The significant difference was also detected in parameters of ρ∞, ρ0, fcα, fcβ and δβ between malignant and benign thyroid tumor tissues. The dielectric properties of the tissue could reflect the changes in the microstructure to a certain extent. These findings provided evidence that there is a certain correlation between the dielectric properties and the nature as well as microstructure of the different types of thyroid tissues, as well as data supporting rapid differentiation and identification of pathological thyroid tissues.
史学涛, 周怡敏, 季振宇, 蔡占秀, 尤富生, 付峰, 董秀珍. 人体正常与肿瘤甲状腺组织10 Hz~100 MHz间介电特性的对比研究[J]. 中国生物医学工程学报, 2018, 37(6): 688-693.
Shi Xuetao, ZhouYimin, Ji Zhenyu, Cai Zhanxiu, You Fusheng, Fu Feng, Dong Xiuzhen. A Comparative Study on Dielectric Properties of Human Thyroid Normal and Tumor Tissues from 10 Hz to 100 MHz. Chinese Journal of Biomedical Engineering, 2018, 37(6): 688-693.
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