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中国生物医学工程学报  2018, Vol. 37 Issue (5): 625-630    DOI: 10.3969/j.issn.0258-8021.2018.05.014
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仿生微流控肝芯片研究进展
厉海笛,陈晓萍*
(浙江工业大学生物工程学院,杭州 310000)
Advances in the Study of Liver-on-Chips with Bionic Microfluidic
Li Haidi, Chen Xiaoping*
(College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310000,China)
全文: PDF (792 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 仿生微流控器官芯片是生物医药研究领域的一个前沿热点,它在微型芯片上建立起模拟人体器官的微组织,并带有高通量检测功能,在药物研发与毒性评价中具有重要的应用前景。肝脏是人体的代谢中枢,易于受到化合物毒害,其肝毒性是药物毒性评价中的重要指标。近年来,有关仿生微流控肝芯片的研究有大量的研究成果。概括和总结这种芯片的基本设计理念、微通道灌流方式、细胞体系,并讨论其主要应用前景和未来的发展趋势。
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厉海笛
陈晓萍
关键词 仿生微流控器官芯片肝毒性    
Abstract:One of the recent frontier hotspots in biomedical field is organ-on-chips with bionic microfluidic. The chips comprise of micro-tissues that mimic in vivo organs and are able to realize high-throughput detection, which have potential wide applications in the drug discovery and toxicity testing. The liver, a metabolic center of human body, is sensitive for chemicals poison and essential to evaluate the hepatotoxicity in toxicity testing. In recent years the advance in this field come out a great deal of results in liver-on-chips with bionic microfluidic. In this review, we provided an overview of the design concepts, micro-channel perfusion methods and cell culture systems. We also discussed the application prospects and the future trends of liver-on-chips.
Key wordsbionic microfluidic    organ-on-chips    hepatotoxicity
收稿日期: 2012-02-02     
PACS:  R318  
基金资助:国家自然科学基金(81241097)
通讯作者: chxp@zjut.edu.cn   
引用本文:   
厉海笛,陈晓萍. 仿生微流控肝芯片研究进展[J]. 中国生物医学工程学报, 2018, 37(5): 625-630.
Li Haidi, Chen Xiaoping. Advances in the Study of Liver-on-Chips with Bionic Microfluidic. Chinese Journal of Biomedical Engineering, 2018, 37(5): 625-630.
链接本文:  
http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2018.05.014     或     http://cjbme.csbme.org/CN/Y2018/V37/I5/625
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