Feature Dimension Reduction of Hepatitis B Virus Reactivation Prediction Model in Patients with Primary Liver Cancer after Precise Radiotherapy
Wang Huina1, Huang Wei2*, Liu Yihui1*
1School of Information, Qilu University of Technology, Jinan 250353, China 2Department of Radiation Oncology VI,Shandong Cancer Hospital, Jinan 250117, China
Abstract：This study established a classification prediction model for hepatitis B virus (HBV) reactivation after the precise radiotherapy in patients with primary liver cancer (PLC), which is expected to use to prevent HBV reactivation and reduce the incidence of the disease. Ninety of HBV-related HCC patients after receiving precise radiotherapy were recruited from Shandong Cancer Hospital. Each sample tests involved thirty characteristics of sexuality, age, KPS score, AFP level, HBV DNA level, tumor stage TNM etc. In this paper, we proposed a sequential feature selection (SFS) method to select key features which would be combined into a brand new feature subset and then establish Bayesian classification prediction model. The method of sequential backward selection (SBS) showed that the KPS score, HBV DNA, outer margin of radiotherapy, TNM, and total hepatic maximum dose were the risk factors that lead to HBV reactivation. The classification accuracy of Bayesian classification reached to 85.75% using 3 fold cross validation. Besides, Sequential forward selection showed that the sexuality, KPS score, HBV DNA, HBeAg and the two kinds of code of outer margin of radiotherapy were the risk factors that lead to HBV reactivation, meanwhile, the classification accuracy of Bayesian classification reached to 84.06% with 5 fold cross validation. The experimental results showed that the Bayesian classification could be used to study the reactivation of HBV. The key feature had a better classification performance after the feature selection.
王会娜, 黄伟, 刘毅慧. 原发性肝癌放疗后乙肝病毒再激活预测模型的特征降维分析[J]. 中国生物医学工程学报, 2017, 36(6): 697-701.
Wang Huina, Huang Wei, Liu Yihui. Feature Dimension Reduction of Hepatitis B Virus Reactivation Prediction Model in Patients with Primary Liver Cancer after Precise Radiotherapy. Chinese Journal of Biomedical Engineering, 2017, 36(6): 697-701.
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