Abstract：This study presented a leaflet motion resistance model of the mitral valve that could simulate the mitral valve dynamics accurately. This model had a variable resistance based on mitral valve leaflet opening angle θ and involved the dynamic control equation of the mitral valve movement and main factors affecting the movement of the leaflets:transvalvular pressure and the blood flow force when it applied in the 0-D lumped parameter model of left heart circulation system, the hemodynamics were derived. The results of this model and step-function with instant valve closure and empirically specified time-varying resistance models were compared under the same cardiac output and regurgitation in left ventricular blood circulation. The leaflet motion resistance model reflected the hemodynamics of the closing process, including the delayed blood flow behind pressure and closing volume. In addition, the model allowed adjustment of the time required for valve opening and closing by changing the impact coefficients of moment of inertial of the leaflet, transvalvular pressure and blood flow-rate, the time of valve opening and closing were 50.0 ms and 40.2 ms. The model eliminated the shortcomings of ignoring leaflet motion of the step-function resistance model and avoided the irrational starting time of valve closing of the time-varying resistance model. The model simulated the mitral valve dynamics accurately and was easy to control.
张桂杰, 王 颢, 荆 腾, 贺照明. 应用于零维左心血液循环的二尖瓣模型的研究[J]. 中国生物医学工程学报, 2017, 36(3): 300-307.
Zhang Guijie, Wang Hao, Jing Teng, He Zhaoming. Research of Mitral Valve Model in the 0D Left Ventricular Circulation System. Chinese Journal of Biomedical Engineering, 2017, 36(3): 300-307.
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