脑深部刺激未来发展的机遇与挑战

doi:10.3969/j.issn.0258-8021. 2015. 04.010

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摘要应对患者数多、病情复杂、药物治疗无效等难题，神经和精神疾病临床治疗面临着重大挑战，脑深部刺激是许多患者唯一可行的临床治疗手段，而达到“治疗效果更好”和“受益人群更大”是脑深部刺激未来发展的两个重要需求。从调控机制研究、智能调控策略、精准手术技术、新适应症推广应用以及术后定量远程康复、先进设备研发和系统综合管理7个方面所面临的科学问题、技术需求和重大突破进行总结和思考，探讨如何针对已有适应症来改善脑深部刺激的临床治疗效果，面向新适应症创新临床治疗方法，降低临床治疗成本，提高临床服务质量，优化医学效能，增强神经调控研究领域的核心竞争力。

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	王守岩^1*王学廉²何江弘³

关键词 ：神经调控, 智能控制, 调控机制, 先进技术

Abstract：The treatment of neurological and psychiatric diseases remains challenging with huge population and lack of effective medication. Deep brain stimulation is an alternative reliable clinical approach for many patients with Parkinson’s disease, pain, etc. There is urgent demand in improving the clinical performance of deep brain stimulation and expanding benefit for larger population. This paper presents perspectives in scientific questions, technologies and key advancements related to the deep brain stimulation, i.e., the mechanisms of neuromodulation, intelligent stimulation strategy, precise operation technique, new indications, quantitative and remote rehabilitation, devices with advanced technology and integrated management system. The goals of future development are to refine deep brain stimulation for existing indications, develop novel clinical approach for new indications, reduce the clinical cost, improve the quality of clinical service, and optimize the medical treatment.

Key words： neuromodulation intelligent control modulation mechanism advanced technology

基金资助:国家自然科学基金（81471745）；苏州市神经工程技术重点实验室(SZS01414)；苏州市医疗器械与新医药专项重点项目(ZXY201425)

引用本文:

王守岩^1*王学廉²何江弘³. 脑深部刺激未来发展的机遇与挑战[J]. 中国生物医学工程学报, 2015, 34(4): 455-463.
Wang Shouyan^1*Wang Xuelian²He Jianghong³. The Opportunities and Challenges of Deep Brain Stimulation in the Future. journal1, 2015, 34(4): 455-463.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021. 2015. 04.010 或 http://cjbme.csbme.org/CN/Y2015/V34/I4/455

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