时间相干电场的外周神经无损刺激

doi:10.3969/j.issn.0258-8021.2020.01.07

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Abstract Peripheral nerve electrical stimulation can be used for sports rehabilitation and chronic neuralgia treatment, but the current spatially selective non-invasive stimulation remains a problem to be solved. A non-invasive peripheral nerve electrical stimulation method that features a certain level of selectivity was developed based on the temporally interfering (TI) electric field. The rat sciatic nerve was tested and the stimulating electrodes were arranged in the direction parallel to the nerve on the ventral and dorsal skin of the thigh. The TI stimulation peak was localized to the nerve for selective stimulation by the scan of interfering electric field. The results showed that optimal electrical parameters, through which the electrical field was delivered to the nerve, could be acquired by scanning without knowing the exact location of the nerve in advance. Thus, selective non-invasive stimulation of nerves could be achieved and the control of the intensity of stimulation could be realized under the premise of keeping the stimulation focus fixed. On this basis, the stimulation threshold I_T of TI electric field on rat sciatic nerve was explored and I_Tof different conditions were measured as well, including fixing frequency difference Δf=0.5 Hz (n=12), changing the frequency f=1～6 kHz and fixed f=5 kHz (n=11), changing the frequency difference Δf=0.5～10 Hz, at the same time, compared with that of equal amplitude kHz electric field (n=7). The results demonstrated that the I_T of the equal-amplitude kHz electric field is significantly higher than that of the TI electric field (P<0.05), and there is a significant difference in the I_T at different frequencies f(P<0.05), while no remarkable difference in the I_T of different Δf(P<0.05), which was different between two frequencies, was observed, indicating that the stimulation threshold of TI electric field on rat sciatic nerve was affected by frather than Δf, and the stimulation threshold I_T was proportional to the frequency f.

Key words： non-invasive stimulation peripheral nerve temporally interfering electric fields

Received: 03 January 2019

PACS:

R318

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	Articles by authors
	Wu Yongliang
	Wang Zimu
	Ding Xiaoyu
	Cang Chen
	Zheng Zheng

Cite this article:

Wu Yongliang,Wang Zimu,Ding Xiaoyu, et al. Peripheral Nerve Noninvasive Stimulation via Temporally Interfering Electric Fields[J]. Chinese Journal of Biomedical Engineering, 2020, 39(1): 50-56.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2020.01.07 OR http://cjbme.csbme.org/EN/Y2020/V39/I1/50

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